Relationship Between Chemokine in Aqueous Humor and Primary Glaucoma: A Meta-Analysis

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2025-02-07 DOI:10.1016/j.ajo.2025.02.002

XIN SUN , JING ZHOU , XIANDONG ZENG , YANHUA JIANG

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引用次数: 0

Abstract

Objective

Glaucoma is a group of diseases characterized by optic nerve damage and corresponding visual field loss as clinical changes. A close relationship has been identified between chemokine in aqueous humor and primary glaucoma; however, this association remains controversial.

Design

Systematic review and meta-analysis.

Methods

The Web of Science, Wiley Online Library, PubMed, and Embase databases were searched. The title or abstract search term “glaucoma” was used together with “chemokine”. Meta-analysis results were presented as the standardized mean difference (SMD) with a corresponding 95% confidence interval (Cl).

Results

Twenty studies were included in this meta-analysis, which showed that patients with primary glaucoma had significantly elevated CCL2 (SMD: 0.48, 95% CI [0.11, 0.86]), CCL4 (SMD: 0.74, 95% CI [0.30, 1.17]), CCL5 (SMD: 0.97, 95% CI [0.07, 1.85]), CCL7 (SMD: 2.28, 95% CI [0.86, 3.71]), CXCL8 (SMD: 1.75, 95% CI [1.04, 2.46]), and CXCL10 (SMD: 1.45, 95% CI [0.46, 2.43]) levels in aqueous humor compared to the control group (P < .05).

Conclusions

This systematic review is the first to systematically and comprehensively evaluate chemokine levels in aqueous humor of patients with primary glaucoma. Clarifying the role of chemokines will be helpful for the treatment of glaucoma.

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来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.