Fe(II), Zn(II), and Ni(II) Complexation of N-Substituted Esters of L-Amino Acids with Heterocyclic Carboxylic Acids as a Way to Prepare Aqueous-Soluble Forms Capable of Inhibiting the Reproduction of the Current Influenza A Strain

Abstract

A series of N-substituted esters of L-amino acids with various heterocyclic and aromatic carboxylic acids were synthesized. To increase the water solubility of the synthesized compounds, they were used as organic ligands in iron(II), zinc(II), and nickel(II) complexation. The antiviral properties of the resulting aqueous solutions were tested against the influenza virus A/IIV-Orenburg/83/2012(H1N1)pdm09 in vitro. It was shown that complexation with iron(II) was the most successful in achieving a high level of viral reproduction suppression compared to nickel and zinc complexes.