Integration of Carboxylate Mesoporous Silica–Coated Solid Phase Microextraction Arrow and Portable Mass Spectrometer for Simultaneous Determination of Five Veterinary Drugs in Chicken and Milk

IF 2.6 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Analytical Methods Pub Date : 2024-10-25 DOI:10.1007/s12161-024-02697-4

Hangzhen Lan, Xueying Li, Zhen Wu, Daodong Pan, Luhong Wen

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引用次数: 0

Abstract

A new solid-phase microextraction (SPME) Arrow device was fabricated using mesoporous silica (MCM-41) as the coating material and integrated with a portable mass spectrometer (PMS) to develop a sensitive and selective method for the detection of amantadine, thiabendazole, sulfadimethoxine, clenbuterol, and ractopamine in milk and chicken samples. The influence of different functional groups on the extraction performance of MCM-41 was investigated by synthesizing amine-, vinyl-, and carboxyl-modified MCM-41, representing basic, neutral, and acidic surface properties. Among these, the carboxyl-modified MCM-41 (MCM-41-C) exhibited the highest selectivity and adsorption capacity, attributed to its strong electrostatic interactions and hydrogen bonding with the analytes. The MCM-41-C-SPME Arrow was fabricated using electrospinning to produce a uniform, stable coating, which was then systematically optimized for key extraction and desorption parameters. This novel SPME Arrow-PMS platform enables rapid detection of five analytes within 30 s, with a broad linear range (5–1000 μg kg^–1) and low limits of detection (1.6–30.6 μg kg^–1). The developed method demonstrated excellent intra-day and inter-day reproducibility (RSD < 12%) and high recovery (82–117%). This method offers rapid, sensitive detection of multiple veterinary drugs in complex food matrices, providing a practical solution for on-site food safety monitoring.

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来源期刊

Food Analytical Methods 农林科学-食品科技

CiteScore

6.00

自引率

3.40%

发文量

244

审稿时长

3.1 months

期刊介绍： Food Analytical Methods publishes original articles, review articles, and notes on novel and/or state-of-the-art analytical methods or issues to be solved, as well as significant improvements or interesting applications to existing methods. These include analytical technology and methodology for food microbial contaminants, food chemistry and toxicology, food quality, food authenticity and food traceability. The journal covers fundamental and specific aspects of the development, optimization, and practical implementation in routine laboratories, and validation of food analytical methods for the monitoring of food safety and quality.