Post-traumatic stress disorder and risk of systemic lupus erythematosus: Meta-analysis and Mendelian randomization study

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-02-03 DOI:10.1016/j.jpsychores.2025.112049

Lingfeng Chen , Mengge Zhang , Shate Xiang , Jingjing Zhang , Runyu Chang , Chao Hu , Suhai Qian , Ting Liu , Yufeng Shi , Xinghong Ding

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引用次数: 0

Abstract

Objective

We conducted a meta-analysis and Mendelian randomization study to analyze the association and causal relationship of genetic prediction between post-traumatic stress disorder and the risk of systemic lupus erythematosus.

Methods

A meta-analysis was conducted using hazard ratio, relative risk, odds ratio, and 95 % confidence intervals as effect measures. Summary data from genome-wide association studies on post-traumatic stress disorder and systemic lupus erythematosus were utilized to assess the causal relationship of genetic prediction between post-traumatic stress disorder and systemic lupus erythematosus using Mendelian randomization.

Results

A meta-analysis showed that post-traumatic stress disorder was positively associated with the risk of systemic lupus erythematosus (RR = 1.85, 95 % CI = 1.61–2.12, p < 0.001). The results of Egger's test showed no publication bias (p = 0.823, p > 0.05). Sensitivity analysis showed that the meta-analysis results were stable (RR = 1.85, 95 % CI = 1.61–2.12). However, Mendelian Randomization analysis revealed no evidence of a causal relationship of genetic prediction between post-traumatic stress disorder and systemic lupus erythematosus (IVW OR: 1.001, 95 % CI: 0.805–1.245, p = 0.993).

Conclusion

There is a correlation between post-traumatic stress disorder and systemic lupus erythematosus, but Mendelian Randomization does not support a genetic causal effect of post-traumatic stress disorder on systemic lupus erythematosus. The potential causal relationship between the two factors may necessitate further in-depth research.

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创伤后应激障碍与系统性红斑狼疮的风险：荟萃分析和孟德尔随机化研究

目的通过荟萃分析和孟德尔随机化研究，分析创伤后应激障碍与系统性红斑狼疮发病风险的遗传预测相关性和因果关系。方法采用风险比、相对危险度、优势比和95%置信区间进行meta分析。利用创伤后应激障碍与系统性红斑狼疮全基因组关联研究的汇总数据，采用孟德尔随机化方法评估创伤后应激障碍与系统性红斑狼疮遗传预测之间的因果关系。结果meta分析显示，创伤后应激障碍与系统性红斑狼疮风险呈正相关(RR = 1.85, 95% CI = 1.61 ~ 2.12, p <；0.001)。Egger检验结果显示无发表偏倚(p = 0.823, p >；0.05)。敏感性分析显示meta分析结果稳定（RR = 1.85, 95% CI = 1.61 ~ 2.12）。然而，孟德尔随机化分析显示，创伤后应激障碍与系统性红斑狼疮之间没有遗传预测的因果关系（IVW OR: 1.001, 95% CI: 0.805-1.245, p = 0.993）。结论创伤后应激障碍与系统性红斑狼疮存在相关性，但孟德尔随机化不支持创伤后应激障碍与系统性红斑狼疮存在遗传因果关系。这两个因素之间潜在的因果关系可能需要进一步深入研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.