Rheumatoid arthritis in the hands

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder resulting from a T-cell-mediated immune response against soft tissues. Among the various joints affected, the hands are particularly susceptible, leading to joint destruction, deformity, significant disability and decreased quality of life for those affected. In the hands, RA predominantly affects the wrist joint and metacarpophalangeal (MCP) joints. In the early stages signs can be subtle, including joint pain and morning stiffness; however, as the disease progresses more severe symptoms and complications can occur, such as deformities of the hand and tendon ruptures. Significant advances in pharmacological treatments has meant there is less need for surgical intervention. With research still ongoing for pharmacological interventions, there are many promising treatments for RA.