Safety of Shear Wave Elastography as Evidenced From Carotid Artery Strain and Strain Rate Induced by Acoustic Radiation Force Impulse and Arterial Pulsations

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2025-02-06 DOI:10.1016/j.ultrasmedbio.2024.12.004

Tim Nordenfur , Kenneth Caidahl , Linnea Lindberg , Matthew W. Urban , Matilda Larsson

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引用次数: 0

Abstract

Objective

The aim of this study was to investigate the mechanical effects of carotid shear wave elastography (SWE) in vivo as its effects on the arterial wall have not been thoroughly examined.

Methods

We evaluated the mechanical effects of carotid SWE in vivo in terms of the radial strain and strain rate to which acoustic radiation force impulses (ARFIs) expose the arterial wall, and compared them with the strain and strain rate induced by arterial pulsation in 13 healthy study subjects (seven individuals 20–35 y of age and six individuals 50–65 y of age). Additionally, we explored whether mechanical effects vary with timing of ARFI and subject age.

Results

The young cohort was found to have, compared with the old cohort, a higher diastolic ARFI-induced peak strain (p = 0.002) and peak strain rate (p = 0.001), and a lower diastolic ARFI-induced peak negative strain rate (p = 0.013). When comparing cardiac phases, diastolic ARFIs were found to induce a lower peak negative strain rate than systolic ARFIs (p = 0.006). Importantly, ARFI-induced peak strain was lower than that caused by arterial pulsation in both age cohorts (p < 0.0001). The ARFI-induced peak strain rate was slightly higher than that caused by arterial pulsation at rest but lower than published exercise data. The ARFI-induced peak negative strain rate was similar to that caused by arterial pulsation.

Conclusion

Our results indicate that arterial SWE does not expose the arterial wall to any higher strain or strain rate than is experienced during normal arterial pulsation. Further research is required to validate the results in arteries containing vulnerable plaques.

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由声辐射力脉冲和动脉脉动诱导的颈动脉应变和应变率证明横波弹性成像的安全性。

目的：本研究的目的是研究颈动脉剪切波弹性成像（SWE）在体内对动脉壁的力学影响，因为它对动脉壁的影响尚未得到彻底的研究。方法：我们根据声辐射力脉冲（arfi）暴露动脉壁的径向应变和应变率来评估颈动脉SWE在体内的力学效应，并将其与13名健康受试者（7名20-35岁，6名50-65岁）动脉脉动引起的应变和应变率进行比较。此外，我们探讨了机械效应是否随ARFI的时间和受试者年龄而变化。结果：与老年组相比，年轻组舒张期arfi诱发的峰值应变（p = 0.002）和峰值应变率（p = 0.001）较高，舒张期arfi诱发的峰值负应变率较低（p = 0.013）。当比较心脏期时，发现舒张期arfi诱导的峰值负应变率低于收缩期arfi （p = 0.006）。重要的是，在两个年龄组中，arfi诱导的峰值应变均低于动脉搏动引起的峰值应变（p < 0.0001）。arfi诱导的峰值应变率略高于静止时动脉搏动引起的峰值应变率，但低于已发表的运动数据。arfi诱导的峰值负应变率与动脉搏动引起的峰值负应变率相似。结论：我们的研究结果表明，动脉SWE不会使动脉壁暴露于比正常动脉搏动时更高的应变或应变速率。需要进一步的研究来验证含有易损斑块的动脉的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.