The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes.

IF 2.1 4区医学 Q3 GENETICS & HEREDITY

BMC Medical Genomics Pub Date : 2025-02-07 DOI:10.1186/s12920-025-02094-8

Anthony Yazbeck, Reem Akika, Zainab Awada, Nathalie K Zgheib

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引用次数: 0

Abstract

Background: This study aims to investigate the association between candidate host genetic polymorphisms and COVID-19 susceptibility, severity, hospitalization, hypoxia, and their combined effect, measured by the polygenic risk score (PRS).

Methods: Three hundred and seventy-six Lebanese participants, comprising 151 controls and 225 cases, were included. Clinical data were obtained from questionnaires and medical records. DNA isolated from peripheral blood was genotyped for ACE1 rs1799752, ACE2 rs2074192, TMPRSS2 rs75603675 and OAS1 rs107746771 using TaqMan assays, and for TMPRSS2 rs35074065 using Sanger Sequencing. Candidate genetic variants were analyzed in association with COVID-19 susceptibility, severity, hospitalization and hypoxia, using univariate and multivariate models. PRS constructed from the weighted sum of variants was evaluated in association with COVID-19 outcomes.

Results: In this study, there were no statistically significant differences in the frequencies of candidate variant alleles between cases, controls and within disease outcomes subgroups, after adjustment for confounders. PRS was not associated with COVID-19 susceptibility and hospitalization, it however significantly predicted COVID-19 severity (P = 0.01).

Conclusion: This study highlights the importance of genetic testing for key host genes involved in COVID-19 life cycle and eventually measuring the PRS which proves to be an important tool for prognosis assessment in vulnerable individuals, potentially enhancing patient care.

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候选遗传多态性在covid-19易感性和结局中的作用

背景：本研究旨在通过多基因风险评分（PRS）研究候选宿主遗传多态性与COVID-19易感性、严重程度、住院、缺氧及其综合效应的关系。方法：376名黎巴嫩参与者，包括151名对照和225例病例。临床资料来源于问卷调查和医疗记录。采用TaqMan法分型ACE1 rs1799752、ACE2 rs2074192、TMPRSS2 rs75603675和OAS1 rs107746771，采用Sanger测序法分型TMPRSS2 rs35074065。使用单变量和多变量模型分析候选遗传变异与COVID-19易感性、严重程度、住院和缺氧的相关性。由变异加权和构建的PRS与COVID-19结局的相关性进行了评估。结果：在本研究中，在调整混杂因素后，病例、对照组和疾病结局亚组内候选变异等位基因的频率没有统计学上的显著差异。PRS与COVID-19易感性和住院率无相关性，但与COVID-19严重程度有显著相关性（P = 0.01）。结论：本研究强调了对参与COVID-19生命周期的关键宿主基因进行基因检测的重要性，并最终测量PRS，这被证明是易感个体预后评估的重要工具，有可能加强患者护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Genomics 医学-遗传学

CiteScore

3.90

自引率

0.00%

发文量

243

审稿时长

3.5 months

期刊介绍： BMC Medical Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.