The transcription factor STAT3 and aging: an intermediate medium.

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-02-07 DOI:10.1007/s10522-025-10193-3

Min Shi, Honyu Li, Runyu Liang, Haiyan Lin, Qiang Tang

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引用次数: 0

Abstract

Aging is a physiological/pathological process accompanied by progressive impairment of cellular function, leading to a variety of aging-related diseases. STAT3 is one of the core regulatory factors of aging. It is involved in body metabolism, development and senescence, cell apoptosis and so on. During the aging process, the changes of growth factors and cytokines will cause the activation of STAT3 to varying degrees, regulate the inflammatory pathways related to aging, regulate body inflammation, mitochondrial function, cell aging and autophagy to regulate and influence the aging process. Drugs targeting STAT3 can treat senescence related diseases. This review summarizes the role of STAT3 signaling factors in the pathogenesis of aging, including mitochondrial function, cellular senescence, autophagy, and chronic inflammation mediated by inflammatory pathways. Finally, the key regulatory role of STAT3 in senescence related diseases is emphasized. In summary, we reveal that drug development and clinical application targeting STAT3 is one of the key points in delaying aging and treating aging-related diseases in the future.

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转录因子STAT3与衰老：一种中间介质。

衰老是伴随细胞功能进行性损伤而导致各种衰老相关疾病的生理/病理过程。STAT3是衰老的核心调控因子之一。参与机体代谢、发育和衰老、细胞凋亡等过程。在衰老过程中，生长因子和细胞因子的变化会引起STAT3不同程度的激活，调节与衰老相关的炎症通路，调节机体炎症、线粒体功能、细胞衰老和自噬，从而调节和影响衰老过程。以STAT3为靶点的药物可以治疗衰老相关疾病。本文综述了STAT3信号因子在衰老发病机制中的作用，包括线粒体功能、细胞衰老、自噬和炎症途径介导的慢性炎症。最后，强调STAT3在衰老相关疾病中的关键调控作用。综上所述，我们揭示了靶向STAT3的药物开发和临床应用是未来延缓衰老和治疗衰老相关疾病的关键之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.