Microwave ablation vs. liver resection for patients with hepatocellular carcinomas.

Journal of liver cancer Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI:10.17998/jlc.2025.02.02
Hyundam Gu, Yeonjoo Seo, Dong Jin Chung, Kwang Yeol Paik, Seung Kew Yoon, Jihye Lim
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Abstract

Backgrounds/aims: Microwave ablation (MWA) is an emerging ablative therapy that surpasses previous methods by achieving higher temperatures and creating larger ablation zones within shorter periods. This study compared the therapeutic outcomes of MWA with those of liver resection in real-world clinical practice.

Methods: A total of 178 patients with 259 nodules who underwent MWA or liver resection between January 2015 and July 2023 were enrolled. Local tumor progression (LTP)-free survival, overall progression (OP)-free survival, and overall survival (OS) were assessed based on the treatment modality for the index nodule.

Results: Of the 178 patients, 134 with 214 nodules underwent MWA, and 44 with 45 nodules underwent liver resection. The median follow-up period was 2.0±1.5 years. The annual incidence of LTP was 3.7% for MWA and 1.4% for liver resection. Treatment modality did not significantly affect LTP-free survival (hazard ratio, 0.61; 95% confidence interval, 0.14-2.69; P=0.511). For nodules larger than 3 cm, LTP-free survival was not affected by the treatment modality. Similarly, OP-free survival and OS were not influenced by treatment modality.

Conclusions: MWA and liver resection demonstrated comparable treatment outcomes in terms of local tumor control, overall recurrence, and survival. MWA may be an alternative treatment option for select patients; however, further studies are necessary to generalize these findings.

微波消融与肝切除术治疗肝细胞癌的疗效比较。
背景/目的:微波消融(MWA)是一种新兴的消融治疗方法,通过在更短的时间内实现更高的温度和更大的消融区域,超越了以前的方法。本研究比较了MWA与肝切除在实际临床中的治疗效果。方法:在2015年1月至2023年7月期间,共有178例259个结节接受了MWA或肝切除术。根据指标结节的治疗方式评估局部肿瘤无进展生存期(LTP)、总无进展生存期(OP)和总生存期(OS)。结果:178例患者中,134例(214个结节)行MWA, 44例(45个结节)行肝切除术。中位随访期为2.0±1.5年。MWA的LTP年发病率为3.7%,肝切除术的LTP年发病率为1.4%。治疗方式对无ltp生存无显著影响(风险比:0.61,95%可信区间:0.14-2.69,P = 0.511)。对于大于3cm的结节,无ltp生存不受治疗方式的影响。同样,无手术生存期和OS不受治疗方式的影响。结论:MWA和肝切除术在局部肿瘤控制、总复发率和生存率方面具有可比性。MWA可能是特定患者的替代治疗选择;然而,需要进一步的研究来推广这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.90
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