Neural biomarkers of age-related memory change.

Abstract

The present study investigates whether electroencephalogram activity reflects age-related memory changes during encoding. We recorded scalp electroencephalogram in 151 young adults (aged 18-30) and 37 older adults (aged 60-85) as they memorized lists of words. Participants studied the word lists either under full attention or while performing a secondary task that required them to make semantic judgments about each word. Although the secondary task reduced recall among all participants, differences in recall performance between the age groups were smaller when participants performed a secondary task at encoding. Older adults also exhibited distinct neural subsequent memory effects, characterized by less negativity in the alpha frequencies compared to young adults. Multivariate classifiers trained on neural features successfully predicted subsequent memory at the trial level in both young and older adults, and captured the differential effects of task demands on memory performance between young and older adults. The findings indicate that neural biomarkers of successful memory vary with both cognitive aging and task demands. (PsycInfo Database Record (c) 2025 APA, all rights reserved).