Relationship of Plasma Cell Infiltration Rates with ¹⁸F-FDG PET/CT Data and Hematological Parameters in Multiple Myeloma.

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Radionuclide Therapy Pub Date : 2025-02-07 DOI:10.4274/mirt.galenos.2024.78557

Özge Ulaş Babacan, Zekiye Hasbek, Hatice Terzi

{"title":"Relationship of Plasma Cell Infiltration Rates with 18F-FDG PET/CT Data and Hematological Parameters in Multiple Myeloma.","authors":"Özge Ulaş Babacan, Zekiye Hasbek, Hatice Terzi","doi":"10.4274/mirt.galenos.2024.78557","DOIUrl":null,"url":null,"abstract":"Objectives: This study aimed to evaluate the relationship between the degree of bone marrow involvement, hematological parameters, and 18F-fluorodeoxyglucose (18F-FDG)-positron emission tomography/computed tomography (PET/CT) data in patients diagnosed with multiple myeloma.Methods: A total of 71 patients [19 females, 52 males, mean age 67 (36-83) years] who were diagnosed with multiple myeloma between 2014 and 2021, had not received any treatment yet, and underwent 18F-FDG-PET/CT for staging were included in the study.Results: No significant correlation was observed between bone marrow standardized uptake value (SUV)max and plasma cell infiltration (p=0.07). However, we found that patients with visually increased bone marrow counts also had higher plasma cell infiltration rates (p=0.037). No significant correlation was found between plasma cell infiltration rates and bone marrow SUVmax and systemic inflammatory index (SII) (p=0.187 and p=0.446, respectively). However, there was a significant correlation between the SUVmax of lytic lesions showing increased 18F-FDG uptake in bone and SII (p=0.025, r=0.330).Conclusion: We believe that 18F-FDG PET/CT may be an advantage over bone marrow biopsy in the diagnosis and evaluation of multiple myeloma recurrence and may prevent repeated bone marrow biopsies.","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 1","pages":"26-30"},"PeriodicalIF":0.9000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827519/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Imaging and Radionuclide Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/mirt.galenos.2024.78557","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: This study aimed to evaluate the relationship between the degree of bone marrow involvement, hematological parameters, and ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG)-positron emission tomography/computed tomography (PET/CT) data in patients diagnosed with multiple myeloma.

Methods: A total of 71 patients [19 females, 52 males, mean age 67 (36-83) years] who were diagnosed with multiple myeloma between 2014 and 2021, had not received any treatment yet, and underwent ¹⁸F-FDG-PET/CT for staging were included in the study.

Results: No significant correlation was observed between bone marrow standardized uptake value (SUV)_max and plasma cell infiltration (p=0.07). However, we found that patients with visually increased bone marrow counts also had higher plasma cell infiltration rates (p=0.037). No significant correlation was found between plasma cell infiltration rates and bone marrow SUV_max and systemic inflammatory index (SII) (p=0.187 and p=0.446, respectively). However, there was a significant correlation between the SUV_max of lytic lesions showing increased ¹⁸F-FDG uptake in bone and SII (p=0.025, r=0.330).

Conclusion: We believe that ¹⁸F-FDG PET/CT may be an advantage over bone marrow biopsy in the diagnosis and evaluation of multiple myeloma recurrence and may prevent repeated bone marrow biopsies.

查看原文本刊更多论文

多发性骨髓瘤血浆细胞浸润率与18F-FDG PET/CT数据及血液学参数的关系

目的：本研究旨在评估多发性骨髓瘤患者骨髓受累程度、血液学参数与18f -氟脱氧葡萄糖(18F-FDG)-正电子发射断层扫描/计算机断层扫描（PET/CT）数据之间的关系。方法：选取2014 - 2021年间确诊为多发性骨髓瘤、未接受任何治疗并行18F-FDG-PET/CT分期的患者71例，其中女性19例，男性52例，平均年龄67（36-83）岁。结果：骨髓标准化摄取值（SUV）max与浆细胞浸润无显著相关性（p=0.07）。然而，我们发现骨髓计数明显增加的患者浆细胞浸润率也较高（p=0.037）。浆细胞浸润率与骨髓SUVmax、全身炎症指数（SII）无显著相关性（p=0.187、p=0.446）。然而，溶解性病变的SUVmax显示骨中18F-FDG摄取增加，与SII之间存在显著相关性（p=0.025, r=0.330）。结论：我们认为18F-FDG PET/CT在诊断和评估多发性骨髓瘤复发方面可能比骨髓活检更有优势，并且可以防止重复骨髓活检。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.