An undescribed jatrophane diterpenoid along with known compounds from Euphorbia sororia with tumour multidrug resistance reversal ability.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-02-07 DOI:10.1080/14786419.2025.2462113

Hequn Yang, Dan Tang, Jiangyu Zhao, Haji Akber Aisa

引用次数: 0

Abstract

An undescribed jatrophane diterpenoid, euphosorophane N (1), along with thirteen known jatrophane diterpenoids (2-14), were isolated from the fructus of Euphorbia sororia, and their chemical structures were elucidated based on extensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR data. The X-ray crystallographic analysis was used to confirm the absolute configurations of compound 6 for the first time. These jatrophane diterpenoids were evaluated for their multidrug resistance (MDR) reversal ability on the cancer cell line HCT-8/Taxol by MTT assay and compounds 3, 5, and 9 revealed promising MDR reversal ability compared to verapamil (VRP).

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.