Jianxun Ren, Ning An, Cong Lin, Youjia Zhang, Zhenyu Sun, Wei Zhang, Shiyi Li, Ning Guo, Weigang Cui, Qingyu Hu, Weiwei Wang, Xuehai Wu, Yinyan Wang, Tao Jiang, Theodore D Satterthwaite, Danhong Wang, Hesheng Liu
{"title":"DeepPrep: an accelerated, scalable and robust pipeline for neuroimaging preprocessing empowered by deep learning.","authors":"Jianxun Ren, Ning An, Cong Lin, Youjia Zhang, Zhenyu Sun, Wei Zhang, Shiyi Li, Ning Guo, Weigang Cui, Qingyu Hu, Weiwei Wang, Xuehai Wu, Yinyan Wang, Tao Jiang, Theodore D Satterthwaite, Danhong Wang, Hesheng Liu","doi":"10.1038/s41592-025-02599-1","DOIUrl":null,"url":null,"abstract":"<p><p>Neuroimaging has entered the era of big data. However, the advancement of preprocessing pipelines falls behind the rapid expansion of data volume, causing substantial computational challenges. Here we present DeepPrep, a pipeline empowered by deep learning and a workflow manager. Evaluated on over 55,000 scans, DeepPrep demonstrates tenfold acceleration, scalability and robustness compared to the state-of-the-art pipeline, thereby meeting the scalability requirements of neuroimaging.</p>","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":" ","pages":""},"PeriodicalIF":36.1000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Methods","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41592-025-02599-1","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Neuroimaging has entered the era of big data. However, the advancement of preprocessing pipelines falls behind the rapid expansion of data volume, causing substantial computational challenges. Here we present DeepPrep, a pipeline empowered by deep learning and a workflow manager. Evaluated on over 55,000 scans, DeepPrep demonstrates tenfold acceleration, scalability and robustness compared to the state-of-the-art pipeline, thereby meeting the scalability requirements of neuroimaging.
期刊介绍:
Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.