Somatic CAG-repeat expansion drives neuronal loss in Huntington's disease.

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-02-05 DOI:10.1016/j.neuron.2025.01.008

Gillian P Bates

引用次数: 0

Abstract

Using single-cell technologies on postmortem brains, Handsaker et al.¹ have demonstrated that substantial somatic expansion of the CAG repeat that causes Huntington's disease results in progressive transcriptional dysregulation and drives the loss of spiny projection neurons in the caudate.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.