Economic Evaluation of Transitioning to the 20-Valent Pneumococcal Conjugate Vaccine in the Dutch Paediatric National Immunisation Programme.

IF 4.7 3区 医学 Q1 INFECTIOUS DISEASES
Infectious Diseases and Therapy Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI:10.1007/s40121-025-01109-2
Esra Çakar, An Ta, Michel Peters, Elizabeth Vinand, Angela Waterval-Overbeek, Aleksandar Ilic, Johnna Perdrizet
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引用次数: 0

Abstract

Introduction: In 2024, the vaccination strategy against pneumococcal disease in the Dutch paediatric population was changed from the 10-valent pneumococcal conjugate vaccine (PCV) (PCV10) to a 15-valent PCV (PCV15) under a 2 + 1 schedule. We aimed to assess whether switching from PCV15 under a 2 + 1 schedule to 20-valent PCV (PCV20) under a 3 + 1 schedule in the Dutch paediatric national immunisation programme (NIP) would yield economic savings and health benefits.

Methods: A multiple-cohort population model with an annual cycle and 10-year time horizon was adapted for the Dutch population from a societal perspective. Discounting was set at 3.0% and 1.5% for costs and benefits, respectively. Medical and societal costs were calculated, along with cases of invasive and non-invasive pneumococcal disease, and quality-adjusted life years (QALY) for PCV15 and PCV20, from which, the incremental cost-effectiveness ratio (ICER) per QALY was calculated for PCV20 versus PCV15 to determine the economic benefits of PCV20. The model assumptions were tested in probabilistic and deterministic sensitivity analyses, as well as a series of scenario analyses.

Results: Both medical and societal cost of disease were substantially lower with PCV20 versus PCV15 (incremental cost-savings of €130,113,010 and €61,593,168, respectively), with total incremental cost-savings of €29,365,696 when considering the cost of the vaccination programme. With an overall QALY gain of 33,232, the ICER per QALY placed PCV20 as the dominant strategy, as it was both more effective and less costly than PCV15. PCV20 was estimated to result in 57,657 fewer pneumococcal disease cases across invasive and non-invasive disease and 1561 fewer disease-related deaths. The sensitivity and scenario analyses demonstrated the robustness of the model results.

Conclusion: This cost-effectiveness analysis demonstrated that switching from PCV15 2 + 1 to PCV20 3 + 1 in the Dutch paediatric NIP would reduce both the clinical burden and projected costs of pneumococcal disease over 10 years.

在荷兰儿童国家免疫规划中过渡到20价肺炎球菌结合疫苗的经济评估。
2024年,荷兰儿科人群的肺炎球菌疾病疫苗接种策略从10价肺炎球菌结合疫苗(PCV) (PCV10)改为15价PCV (PCV15),按2 + 1时间表进行。我们的目的是评估在荷兰儿科国家免疫规划(NIP)中,从2 + 1计划下的PCV15转换为3 + 1计划下的20价PCV20是否会产生经济节约和健康效益。方法:从社会角度对荷兰人口采用了一个年周期和10年时间范围的多队列人口模型。成本和收益的折扣率分别为3.0%和1.5%。计算PCV15和PCV20的医疗和社会成本,以及侵袭性和非侵袭性肺炎球菌疾病的病例,以及质量调整生命年(QALY),由此计算PCV20与PCV15的每个QALY的增量成本-效果比(ICER),以确定PCV20的经济效益。在概率和确定性敏感性分析以及一系列情景分析中对模型假设进行了检验。结果:与PCV15相比,PCV20的疾病医疗和社会成本都大大降低(分别为130,113,010欧元和61,593,168欧元的增量成本节约),考虑到疫苗接种计划的成本,总增量成本节约为29,365,696欧元。由于QALY的总体增益为33,232,每个QALY的ICER将PCV20作为主要策略,因为它比PCV15更有效且成本更低。据估计,PCV20在侵袭性和非侵袭性疾病中导致肺炎球菌疾病病例减少57,657例,疾病相关死亡减少1561例。敏感性分析和情景分析证明了模型结果的稳健性。结论:该成本-效果分析表明,在荷兰儿科NIP中,从PCV15 2 + 1转换为PCV20 3 + 1将在10年内减少肺炎球菌疾病的临床负担和预计成本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Infectious Diseases and Therapy
Infectious Diseases and Therapy Medicine-Microbiology (medical)
CiteScore
8.60
自引率
1.90%
发文量
136
审稿时长
6 weeks
期刊介绍: Infectious Diseases and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of infectious disease therapies and interventions, including vaccines and devices. Studies relating to diagnostic products and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to, bacterial and fungal infections, viral infections (including HIV/AIDS and hepatitis), parasitological diseases, tuberculosis and other mycobacterial diseases, vaccinations and other interventions, and drug-resistance, chronic infections, epidemiology and tropical, emergent, pediatric, dermal and sexually-transmitted diseases.
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