Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer.

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Frontiers in Molecular Biosciences Pub Date : 2025-01-23 eCollection Date: 2024-01-01 DOI:10.3389/fmolb.2024.1520223

L S Franco, S Arunachalam, A Chauhan, S A Kareff, P L Hallenbeck

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引用次数: 0

Abstract

The TEM8 protein coded by the ANTXR1 gene represents an emerging biomarker in solid tumors. In addition to the various roles TEM8 plays in oncogenesis, including angiogenesis, epithelial-to-mesenchymal transition, and cell migration, it has also been shown that the overexpression of the ANTXR1 gene in solid tumors correlates with poor prognostic indicators in several solid tumor histologies. As such, TEM8 has been identified as the target of novel oncologic therapies. It is especially attractive given its selective expression on the surface of solid tumor cells and associated stromal cells, such as cancer stem cells, invasive cancer cells, and immune cells, such as macrophages, angiogenic endothelial cells, pericytes, and cancer-associated fibroblasts. Furthermore, TEM8 plays this unique role as a mostly non-mutated gene in solid cancers. Here, we demonstrate that elevated expression of ANTXR1 in bladder cancer showed a statistical difference not only in overall survival (OS) but in progression-free survival (PFS), confirming the prognostic biomarker power of ANTXR1 expression.

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肿瘤中ANTXR1基因表达升高是膀胱癌患者预后不良的生物标志物。

由ANTXR1基因编码的TEM8蛋白代表了实体瘤中新兴的生物标志物。除了TEM8在肿瘤发生中发挥的各种作用，包括血管生成、上皮-间质转化和细胞迁移，也有研究表明，实体瘤中ANTXR1基因的过表达与几种实体瘤组织学中的不良预后指标相关。因此，TEM8已被确定为新型肿瘤治疗的靶点。考虑到它在实体肿瘤细胞和相关基质细胞（如癌症干细胞、侵袭性癌细胞和免疫细胞，如巨噬细胞、血管内皮细胞、周细胞和癌症相关成纤维细胞）表面的选择性表达，它尤其具有吸引力。此外，TEM8在实体癌中发挥着这种独特的作用，它是一种大多数不突变的基因。在这里，我们证明ANTXR1在膀胱癌中的表达升高不仅在总生存期（OS）和无进展生存期（PFS）上都有统计学差异，证实了ANTXR1表达的预后生物标志物能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.