Prognostic role of prognostic nutritional index in patients with bladder cancer: a systematic review and meta-analysis.

IF 3.5 3区医学 Q2 ONCOLOGY

Frontiers in Oncology Pub Date : 2025-01-23 eCollection Date: 2024-01-01 DOI:10.3389/fonc.2024.1486389

Jing Sun, Zhenzhen Li, Xiaming Zhu

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引用次数: 0

Abstract

Aims: An increasing number of studies have explored the prognostic significance of the prognostic nutritional index (PNI) in bladder cancer patients, but the results are inconsistent. This study systematically investigates the prognostic value of baseline PNI in patients with bladder cancer through a meta-analytic approach.

Methods: The databases of PubMed, EmBase, and the Cochrane library were systematically searched for eligible studies from inception until April 2024. The prognostic outcomes including overall survival (OS) and recurrence-free survival (RFS). The summary outcomes were calculated using the random-effects model, and the exploratory analyses were performed by sensitivity and subgroup analyses.

Results: Twelve retrospective studies involved 2,951 patients with bladder cancer were selected in final analysis. The summary results found low PNI were associated with poor OS (HR: 1.80; 95%CI: 1.54-2.10; P<0.001) and RFS (HR: 1.53; 95%CI: 1.15-2.04; P=0.003). The association between low PNI and shorter OS was statistically significant in all subgroups. Additionally, the association between low PNI and RFS was also significant in most subgroups.

Conclusions: This study found a significant association between low PNI and poor prognosis in bladder cancer patients. Further large-scale prospective study should be performed to verify this association, and assess the nutrition interventions for patients with bladder cancer.

Systematic review registration: https://inplasy.com/inplasy-2024-8-0020/, identifier INPLASY202480020.

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来源期刊

Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

6.20

自引率

10.60%

发文量

6641

审稿时长

14 weeks

期刊介绍： Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.