Investigation of patterns and associations of neuroinflammation in cognitive impairment.

IF 2.9 2区医学 Q2 NEUROSCIENCES

Cerebral cortex Pub Date : 2025-02-05 DOI:10.1093/cercor/bhaf013

Ruoqiu Gan, Hongsheng Xie, Ziru Zhao, Xiaoai Wu, Ruihan Wang, Baolin Wu, Qin Chen, Zhiyun Jia

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Abstract

Neuroinflammation has been identified as an important pathological component of cognitive impairment, and translocator protein imaging has become a valuable tool for assessing its patterns. We aimed to obtain the exact distribution of neuroinflammation in cognitive impairment and its underlying mechanisms with amyloid-beta. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, two investigators searched literature databases for studies that measured translocator protein binding levels. This measurement was performed between healthy controls and subjects with mild cognitive impairment or Alzheimer's disease via voxel-based positron emission tomography image analysis at the whole-brain level. This meta-analysis was performed with the anisotropic effect-size based algorithm. Neuroinflammation in patients with mild cognitive impairment was mainly concentrated in the left middle temporal gyrus and left amygdala. In Alzheimer's disease patients, the brain regions involved were the left inferior temporal gyrus, left calcarine fissure/surrounding cortex, left parahippocampal gyrus, right lingual gyrus, and right middle temporal gyrus. In addition, neuroinflammation in patients with cognitive impairment was highly correlated with amyloid-beta deposition in the cortex. This study deepens our understanding of the patterns of neuroinflammation in patients with cognitive impairment and its interaction with amyloid-beta, providing potential insights for therapeutic approaches targeting neuroinflammation in Alzheimer's disease.

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认知障碍中神经炎症的模式和关联的研究。

神经炎症已被确定为认知障碍的重要病理组成部分，转运蛋白成像已成为评估其模式的有价值的工具。我们的目的是通过淀粉样蛋白- β获得认知障碍中神经炎症的确切分布及其潜在机制。根据系统评价和荟萃分析指南的首选报告项目，两位研究者在文献数据库中搜索测量转运蛋白结合水平的研究。通过基于体素的正电子发射断层扫描图像分析，在健康对照组和轻度认知障碍或阿尔茨海默病的受试者之间进行全脑水平的测量。本meta分析采用基于各向异性效应大小的算法进行。轻度认知障碍患者的神经炎症主要集中在左侧颞中回和左侧杏仁核。阿尔茨海默病患者受累的脑区为左侧颞下回、左侧骨裂/周围皮层、左侧海马旁回、右侧舌回和右侧颞中回。此外，认知障碍患者的神经炎症与皮层淀粉样蛋白沉积高度相关。这项研究加深了我们对认知障碍患者神经炎症模式及其与淀粉样蛋白- β相互作用的理解，为针对阿尔茨海默病神经炎症的治疗方法提供了潜在的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebral cortex 医学-神经科学

CiteScore

6.30

自引率

8.10%

发文量

510

审稿时长

2 months

期刊介绍： Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.