Extremely asymmetric ectasia: Tomographically unilateral keratoconus.

IF 3 3区 医学 Q1 OPHTHALMOLOGY
Hasan Shabani, Wishal D Ramdas, Magda A Meester-Smoor, Dimitris Rizopoulos, Caroline C W Klaver, Bart T H van Dooren, Annette J M Geerards
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引用次数: 0

Abstract

Purpose: To investigate the characteristics of apparently stable forms of tomographically unilateral keratoconus (KC).

Methods: In this retrospective case-control study, strict unilaterality criteria were applied to select tomographically unilateral cases with ≥3 years of follow-up. For comparison, a healthy cohort and two bilateral KC cohorts were matched to the tomographically unilateral cases. All patients were selected from The Rotterdam Eye Hospital, whereas healthy controls were selected from the population-based Rotterdam Study. After cohort selection, several risk factors and 25 Pentacam features were assessed. Unaffected (i.e. tomographically non-keratoconic) eyes from the tomographically unilateral cases were compared to matched healthy eyes, matched bilateral KC eyes and affected unilateral KC eyes. Furthermore, affected tomographically unilateral KC eyes were compared to matched bilateral KC eyes. Statistical analysis relied on Wilcoxon signed-rank tests and conditional logistic regression.

Results: From 1006 assessed cases, 18 (1.8%) tomographically unilateral cases were selected. Their median (interquartile range) follow-up was 5.7 (4.3-8) years. Eczema and asthma were more prevalent among tomographically unilateral patients (28% each) compared to bilateral patients (6% and 9%) (p = 0.01 and p = 0.05, signed-rank test). We could not detect meaningful Pentacam differences between unaffected unilateral eyes and matched healthy eyes. Expectedly, significant differences were detected between unaffected unilateral eyes and affected (bilateral or unilateral) eyes. Lastly, the ectatic features of affected unilateral eyes seemed comparable to their bilateral counterparts, but their high-order aberrations were significantly lower.

Conclusion: Our findings support the existence of tomographically unilateral KC. Understanding how tomographic unilaterality ensues may offer valuable insights into KC aetiology.

极度不对称扩张:断层扫描单侧圆锥角膜。
目的:探讨单侧圆锥角膜(KC)的ct表现特征。方法:在本回顾性病例对照研究中,采用严格的单侧标准,选择随访≥3年的单侧ct病例。为了进行比较,一个健康队列和两个双侧KC队列与单侧ct病例相匹配。所有患者均来自鹿特丹眼科医院,而健康对照则来自基于人群的鹿特丹研究。在队列选择后,评估了几个危险因素和25个Pentacam特征。将单侧ct上未受影响(即断层扫描无角膜锥)的眼睛与匹配的健康眼睛、匹配的双侧KC眼睛和受影响的单侧KC眼睛进行比较。此外,将受影响的单侧KC眼与匹配的双侧KC眼进行断层扫描比较。统计分析采用Wilcoxon sign -rank检验和条件逻辑回归。结果:从1006例评估病例中,选择18例(1.8%)单侧断层扫描病例。他们的中位(四分位间距)随访时间为5.7(4.3-8)年。单侧断层扫描患者湿疹和哮喘患病率(各为28%)高于双侧断层扫描患者(分别为6%和9%)(p = 0.01和p = 0.05,有符号秩检验)。我们在未受影响的单侧眼睛和匹配的健康眼睛之间没有发现有意义的Pentacam差异。意料之中的是,在未受影响的单侧眼睛和受影响的(双侧或单侧)眼睛之间发现了显著差异。最后,受影响的单侧眼睛的扩张特征似乎与他们的双侧对应物相当,但他们的高阶像差明显较低。结论:我们的研究结果支持单侧KC的存在,了解单侧KC是如何发生的,可能为了解KC的病因提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Ophthalmologica
Acta Ophthalmologica 医学-眼科学
CiteScore
7.60
自引率
5.90%
发文量
433
审稿时长
6 months
期刊介绍: Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.
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