Small RNA-mediated suppression of sex chromosome meiotic conflicts during Drosophila male gametogenesis.

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Society transactions Pub Date : 2025-02-06 DOI:10.1042/BST20240344

Jeffrey Vedanayagam

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引用次数: 0

Abstract

Meiosis is an evolutionarily conserved process in eukaryotes that ensures equal segregation of alleles and chromosomes during reproduction. Although parity in allelic transmission is the norm, selfish genes such as meiotic drivers can violate Mendel's first law of segregation. Sex chromosome drive is a form of meiotic drive that leads to unequal segregation of sex chromosomes, resulting in sex-ratio distortion and/or sterility in the offspring. Adverse fitness effects due to sex chromosome drive trigger the evolution of suppressors to restore Mendelian segregation. However, the molecular mechanisms by which suppressors emerge and counteract meiotic drive genes remain unclear. Recent studies from Drosophila have shed light on the critical roles of small RNA-mediated post-transcriptional silencing in mitigating sex chromosome meiotic conflicts. This review highlights the recruitment of two distinct small RNA pathways to combat intragenomic conflicts during male gametogenesis and seeks to reveal the impact of molecular arms races between meiotic drivers and their suppressors in shaping genome and sex chromosome evolution.

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小rna介导的果蝇雄性配子发生过程中性染色体减数分裂冲突的抑制。

减数分裂是真核生物在繁殖过程中确保等位基因和染色体平等分离的进化保守过程。虽然等位基因的均等传播是常态，但自私的基因，如减数分裂驱动基因，可能违反孟德尔的第一隔离定律。性染色体驱动是减数分裂驱动的一种形式，它导致性染色体的不平等分离，导致性别比例扭曲和/或后代不育。由于性染色体驱动导致的不利适应度效应触发抑制子的进化以恢复孟德尔分离。然而，抑制因子出现和抵消减数分裂驱动基因的分子机制仍不清楚。最近来自果蝇的研究揭示了小rna介导的转录后沉默在减轻性染色体减数分裂冲突中的关键作用。这篇综述强调了在雄性配子体发生过程中，两种不同的小RNA途径的招募来对抗基因组内冲突，并试图揭示减数分裂驱动因子和它们的抑制因子之间的分子军备竞赛在塑造基因组和性染色体进化中的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemical Society transactions 生物-生化与分子生物学

CiteScore

7.80

自引率

0.00%

发文量

351

审稿时长

3-6 weeks

期刊介绍： Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.