Effectiveness and Safety of Combined Use of Home-Based Radiofrequency Device and Arbutin Cream in Melasma and Facial Rejuvenation

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-02-07 DOI:10.1111/jocd.70007

Lei Zhang, Qian Zhao, Qilei Che, Wenju Wang, Tao Chen, Xiao Tang, Xin Zhao, Nianou Wang, Ke Li, Qingbiao Wa

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Abstract

Background

Melasma and facial aging are prevalent dermatological concerns. The combined use of a home-based radiofrequency (RF) device and a topical depigmentation agent, such as an arbutin-based cream, has shown potential in addressing both conditions.

Aims

This study evaluated the effectiveness and safety of combining a home-based RF device with arbutin cream to treat melasma and facial aging.

Methods

This single-center, open-label study included 38 participants. The treatment involved using a home-based RF device alongside an arbutin cream three times a week for 4 weeks, followed by a 4-week rest period. Key outcomes included changes in modified Melasma Area and Severity Index (mMASI) scores, melanin index (MI), erythema index (EI), facial wrinkles, skin texture, and periorbital dermal thickness. The participants also provided a self-assessment of the treatment efficacy.

Results

After 4 and 8 weeks of treatment, compared with baseline, the mMASI scores decreased by 20.8% and 25.6%, whereas the MI decreased by 22.0% and 22.8%, respectively. The EI decreased by 5.94% and 6.86%, facial wrinkles decreased by 30.9% and 35.9%, and skin texture scores decreased by 19.7% and 21.4% at 4 and 8 weeks posttreatment, respectively. Significant improvements in periorbital dermal thickness and subcutaneous tissue thickness were observed after combined RF and arbutin cream treatment. None of the 38 participants experienced adverse events, and all reported satisfaction with the results.

Conclusion

The combination of a noninvasive home-based RF device and arbutin cream is effective in improving melasma and achieving facial rejuvenation, offering a safe and patient-friendly treatment option.

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.