Chronic Stress and Severe Water Insecurity During the Historic 2022 Drought in Northern Kenya Were Associated With Inflammation Among Daasanach Seminomadic Pastoralists

IF 1.6 4区 医学 Q1 ANTHROPOLOGY
Kedir Teji Roba, Hannah Jacobson, Amanda McGrosky, Srishti Sadhir, Leslie B. Ford, Marcela Pfaff, Elizabeth Y. Kim, Rosemary Nzunza, Matthew Douglass, David R. Braun, Emmanuel Ndiema, Samuel S. Urlacher, Herman Pontzer, Asher Y. Rosinger
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引用次数: 0

Abstract

Objective

Extreme climatic events, like droughts, are increasing in frequency and severity. Droughts disrupt community livelihoods and resources with serious implications for human biology. This study investigated how chronic stress, measured by fingernail cortisol concentration (FCC), and water insecurity status were predictive of C-reactive protein (CRP), a biomarker of inflammation, during a historic drought among Daasanach seminomadic pastoralists.

Methods

Data were collected at the height of the 2022 drought from 128 Daasanach household heads aged 16–80 years in northern Kenya using household surveys, anthropometric measurements, and dried blood spots to assess CRP levels and fingernails to assess FCC. We employed mixed-effects linear and logistic regression models to examine the relationships between log-transformed FCC, high water insecurity status measured via the Household Water Insecurity Experiences (HWISE ≥ 24) scale, and serum-equivalent CRP (log-transformed and dichotomized at mild, low-grade inflammation ≥ 1 mg/L) adjusted for covariates.

Results

The mean serum-equivalent CRP was 4.1 mg/L and 56.3% of Daasanach adults had at least mild, low-grade inflammation. Linear models indicated that ln(FCC) was positively associated with ln(CRP) (β = 0.56, SE = 0.12; p < 0.001). Further, logistic models demonstrated that ln(FCC) (OR = 2.69, 95% CI: 1.84–3.95; p < 0.001) and high water insecurity (OR = 2.23, 95% CI: 1.34–3.72; p = 0.002) were both associated with greater odds of low-grade inflammation.

Conclusion

This study provides evidence for how chronic stress and severe water insecurity may impact inflammation levels among pastoralists during drought. Since inflammation is central to cardiometabolic disease etiology, this is an additional reason to mitigate the negative health impacts of droughts and water insecurity exacerbated by climate change.

Abstract Image

2022年肯尼亚北部历史性干旱期间的慢性压力和严重的水不安全与Daasanach半游牧牧民的炎症有关
干旱等极端气候事件的频率和严重程度都在增加。干旱破坏社区生计和资源,对人类生物学产生严重影响。本研究调查了Daasanach半游牧牧民在历史性干旱期间,通过指甲皮质醇浓度(FCC)测量的慢性应激和水不安全状态如何预测c反应蛋白(CRP),这是一种炎症的生物标志物。方法在2022年干旱高峰期收集肯尼亚北部128名年龄在16-80岁的Daasanach户主的数据,采用家庭调查、人体测量、干血斑评估CRP水平和指甲评估FCC。我们采用混合效应线性和逻辑回归模型来检验对数变换FCC、高水不安全状态(通过家庭水不安全体验量表(HWISE≥24)测量)和血清等效CRP(在轻度、低度炎症≥1 mg/L时进行对数变换和二分类)之间的关系。结果平均血清等效CRP为4.1 mg/L, 56.3%的石蒜成人至少有轻度、低度炎症。线性模型表明,ln(FCC)与ln(CRP)呈正相关(β = 0.56, SE = 0.12;p < 0.001)。此外,logistic模型显示ln(FCC) (OR = 2.69, 95% CI: 1.84-3.95;p < 0.001)和高度水不安全感(OR = 2.23, 95% CI: 1.34-3.72;P = 0.002)均与低度炎症的高发生率相关。结论本研究为长期压力和严重的水不安全如何影响干旱期间牧民的炎症水平提供了证据。由于炎症是心脏代谢疾病病因学的核心,这是减轻气候变化加剧的干旱和水不安全对健康的负面影响的另一个原因。
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来源期刊
CiteScore
4.80
自引率
13.80%
发文量
124
审稿时长
4-8 weeks
期刊介绍: The American Journal of Human Biology is the Official Journal of the Human Biology Association. The American Journal of Human Biology is a bimonthly, peer-reviewed, internationally circulated journal that publishes reports of original research, theoretical articles and timely reviews, and brief communications in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, the Journal also publishes abstracts of research presented at its annual scientific meeting and book reviews relevant to the field. The Journal seeks scholarly manuscripts that address all aspects of human biology, health, and disease, particularly those that stress comparative, developmental, ecological, or evolutionary perspectives. The transdisciplinary areas covered in the Journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology, and evolution, along with their interactions. The Journal publishes basic, applied, and methodologically oriented research from all areas, including measurement, analytical techniques and strategies, and computer applications in human biology. Like many other biologically oriented disciplines, the field of human biology has undergone considerable growth and diversification in recent years, and the expansion of the aims and scope of the Journal is a reflection of this growth and membership diversification. The Journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscripts of unusual interest.
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