Engineering Macrophage-Derived Exosome to Deliver Pirfenidone: A Novel Approach to Combat Silicotic Pulmonary Fibrosis (Adv. Healthcare Mater. 4/2025)

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-02-07 DOI:10.1002/adhm.202570020

Zhen Chen, Xiang Yun, Jiaqi Tian, Fei Li, Zitong Zhang, Jiahua Meng, Ning Li, Hongying Bian, Shuyin Duan, Lin Zhang

引用次数: 0

Abstract

Exosome-Based Nano Drug Delivery System

Macrophage-derived exosomes offer a novel approach to deliver pirfenidone (PFD) for treating silicotic pulmonary fibrosis. In article 2403227, Shuyin Duan, Lin Zhang, and co-workers demonstrate that PFD-loaded exosomes effectively inhibit fibroblast activation and reduce lung fibrosis in a mouse model of silicosis, while potentially mitigating systemic side effects. The cover illustrates lung-originating macrophages secreting exosomes engineered to encapsulate PFD for targeted pulmonary delivery.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.