Enantioselective effects of dinotefuran on physiological parameters in Rana nigromaculata tadpoles

IF 1.7 4区环境科学与生态学 Q3 ECOLOGY

Aquatic Ecology Pub Date : 2024-10-30 DOI:10.1007/s10452-024-10150-1

Fangze Li, Yu Wang, Xiaohuan Wang, Hui Jiao, Lulu Ran, Ping Lu

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引用次数: 0

Abstract

Dinotefuran possesses promising prospects, but poses a threat to the health of organisms in aquatic environment. In this study, the enantioselective toxicity effects of dinotefuran on Rana nigromaculata tadpoles were investigated. Acute toxicity tests for 96 h showed that R-(−)-dinotefuran had a more significant toxic effect on tadpoles than Rac-dinotefuran, which was greater than that of S-(+)-dinotefuran. In the toxicity assays with 0.2 and 2 mg/L dinotefuran for 28 d, noticeable changes in oxidative stress induced by Rac-dinotefuran and the two enantiomers were observed. The results of the growth parameters indicated that the development of R. nigromaculata tadpoles was inhibited to a certain extent, and the order was R-(-)-dinotefuran > Rac-dinotefuran > S-(+)-dinotefuran. Furthermore, the determination of triiodothyronine (T3) and thyroxine (T4), and the expression levels of corresponding genes (dio2, dio3, trα and trβ), demonstrated that R-(-)-dinotefuran and Rac-dinotefuran caused endocrine disruption of the thyroid system and delayed the development and metamorphosis of tadpoles, but S-(+)-dinotefuran had little effect, which was basically consistent with the results of acute toxicity and growth parameter assays. The results provide a new theoretical basis for assessing the environmental risk posed by chiral pesticides to aquatic nontargeted organisms.

Graphical abstract

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呋虫胺对黑斑蛙蝌蚪生理参数的对映选择性影响

呋虫胺具有良好的应用前景，但对水生生物的健康构成威胁。本研究研究了呋虫胺对黑斑蛙蝌蚪的对映选择性毒性作用。96 h急性毒性试验表明，R-(−)-呋虫胺对蝌蚪的毒性作用比racc -呋虫胺更显著，且大于S-(+)-呋虫胺。在0.2和2 mg/L呋虫胺作用28 d的毒性实验中，观察到rac -呋虫胺和两种对映体诱导的氧化应激有明显变化。生长参数结果表明，黑斑田鼠蝌蚪发育受到一定程度的抑制，其抑制顺序为R-(-)-dinotefuran > racc -dinotefuran > S-(+)-dinotefuran。此外，三碘甲状腺原氨酸（T3）和甲状腺素（T4）的测定以及相应基因（dio2、dio3、trα和trβ）的表达水平表明，R-(-)-甲硝呋喃和racc -甲硝呋喃引起蝌蚪甲状腺系统内分泌紊乱，延缓蝌蚪发育和变态，而S-(+)-甲硝呋喃影响很小，这与急性毒性和生长参数试验结果基本一致。研究结果为评价手性农药对水生非靶向生物的环境风险提供了新的理论依据。图形抽象

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来源期刊

Aquatic Ecology 环境科学-海洋与淡水生物学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Aquatic Ecology publishes timely, peer-reviewed original papers relating to the ecology of fresh, brackish, estuarine and marine environments. Papers on fundamental and applied novel research in both the field and the laboratory, including descriptive or experimental studies, will be included in the journal. Preference will be given to studies that address timely and current topics and are integrative and critical in approach. We discourage papers that describe presence and abundance of aquatic biota in local habitats as well as papers that are pure systematic. The journal provides a forum for the aquatic ecologist - limnologist and oceanologist alike- to discuss ecological issues related to processes and structures at different integration levels from individuals to populations, to communities and entire ecosystems.