Physical properties, antimicrobial activity, and molecular docking studies of grafting carboxymethyl cellulose hydrogels using 4-(2-chloroethyl) morpholine hydrochloride

IF 3.1 3区化学 Q2 POLYMER SCIENCE

Polymer Bulletin Pub Date : 2024-11-04 DOI:10.1007/s00289-024-05552-y

Abdullah A. Alamri, Hossam M. Sayed, Khatib S. Ismail, Mohamed R. El-Aassar, Diaa A. Ibrahim, Waleed M. Alamier, Nasser J. Amri, Abdel-Rahman Farghaly

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Abstract

This study investigates the synthesis and characterization of carboxymethyl cellulose (CMC) hydrogels grafted with 4-(2-chloroethyl) morpholine hydrochloride (CEMHD), focusing on their physical properties, antimicrobial activity, and molecular docking studies. The hydrogels were developed using citric acid as a crosslinking agent, and their properties were evaluated at varying concentrations of CEMHD (1%, 5%, 10%, and 15%). The results revealed that increasing the concentration of CEMHD significantly improved the thermal stability and surface morphology of the hydrogels, as shown by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). The antimicrobial activity was enhanced with higher CEMHD concentrations. This research provides a novel approach to the development of functional hydrogels, advancing the scope of biocompatible and antimicrobial materials for medical and industrial use.

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来源期刊

Polymer Bulletin 化学-高分子科学

CiteScore

6.00

自引率

6.20%

发文量

审稿时长

5.5 months

期刊介绍： "Polymer Bulletin" is a comprehensive academic journal on polymer science founded in 1988. It was founded under the initiative of the late Mr. Wang Baoren, a famous Chinese chemist and educator. This journal is co-sponsored by the Chinese Chemical Society, the Institute of Chemistry, and the Chinese Academy of Sciences and is supervised by the China Association for Science and Technology. It is a core journal and is publicly distributed at home and abroad. "Polymer Bulletin" is a monthly magazine with multiple columns, including a project application guide, outlook, review, research papers, highlight reviews, polymer education and teaching, information sharing, interviews, polymer science popularization, etc. The journal is included in the CSCD Chinese Science Citation Database. It serves as the source journal for Chinese scientific and technological paper statistics and the source journal of Peking University's "Overview of Chinese Core Journals."