Virus-inspired biogenic delivery system for advancing cancer therapy

Biomedical Technology Pub Date : 2025-02-08 DOI:10.1016/j.bmt.2025.100069

Di Sun , Hao Liang , Qianwen Mu , Chengchao Chu , Gang Liu , Chao Liu

{"title":"Virus-inspired biogenic delivery system for advancing cancer therapy","authors":"Di Sun , Hao Liang , Qianwen Mu , Chengchao Chu , Gang Liu , Chao Liu","doi":"10.1016/j.bmt.2025.100069","DOIUrl":null,"url":null,"abstract":"<div><div>Virus-inspired particles have been utilized in various applications, including vaccination, gene therapy, drug therapy, and diagnostics. Biogenic delivery systems imitating the natural structure of viruses are regarded as innovative nanoplatforms used to deliver drug compounds to related sites and target cells in organisms. Among them, the components comprised of virus-like particles (VLPs) derive from the proteins or peptides of the viruses; the glycoproteins on their surface exert significant function as specific targeting. Types of assembled glycoproteins and encapsulated drug molecules confer the complexity and varieties of structure, function, and treatment of VLPs. VLPs lack viral virulence, resulting from a viral genetic material deficiency. In vaccine research, Virus-mimic nanovesicles have been effectively verified against cancer via the immunogenicity and the pharmacological effect of drug molecules delivered to mediate an immune response in the body. This review summarizes the research status of virus-inspired drug delivery platforms for cancer therapy utilization.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100069"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949723X25000017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Virus-inspired particles have been utilized in various applications, including vaccination, gene therapy, drug therapy, and diagnostics. Biogenic delivery systems imitating the natural structure of viruses are regarded as innovative nanoplatforms used to deliver drug compounds to related sites and target cells in organisms. Among them, the components comprised of virus-like particles (VLPs) derive from the proteins or peptides of the viruses; the glycoproteins on their surface exert significant function as specific targeting. Types of assembled glycoproteins and encapsulated drug molecules confer the complexity and varieties of structure, function, and treatment of VLPs. VLPs lack viral virulence, resulting from a viral genetic material deficiency. In vaccine research, Virus-mimic nanovesicles have been effectively verified against cancer via the immunogenicity and the pharmacological effect of drug molecules delivered to mediate an immune response in the body. This review summarizes the research status of virus-inspired drug delivery platforms for cancer therapy utilization.

查看原文本刊更多论文

促进癌症治疗的病毒激发生物传递系统

病毒激发颗粒已被用于各种应用，包括疫苗接种、基因治疗、药物治疗和诊断。模仿病毒自然结构的生物源传递系统被认为是一种创新的纳米平台，用于将药物化合物传递到生物体内的相关部位和靶细胞。其中，由病毒样颗粒（vlp）组成的组分来源于病毒的蛋白质或多肽；其表面的糖蛋白具有特异性靶向作用。组装的糖蛋白和包封的药物分子的类型决定了VLPs的结构、功能和治疗的复杂性和多样性。由于病毒遗传物质缺乏，VLPs缺乏病毒毒力。在疫苗研究中，模拟病毒的纳米囊泡通过药物分子的免疫原性和药理学作用在体内介导免疫反应，已被有效地证实具有抗癌作用。本文综述了病毒启发给药平台在肿瘤治疗中的应用研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biomedical Technology

CiteScore

4.10

自引率

0.00%

发文量