Intrastromal autologous implantation of adipose derived adult stem cells for the management of established corneal scars

Q3 Medicine

American Journal of Ophthalmology Case Reports Pub Date : 2025-02-03 DOI:10.1016/j.ajoc.2025.102270

Jorge L. Alio del Barrio , Alberto Parafita-Fernandez , Daniel Gomez Plaza , Maria Eugenia Fernandez , Jorge L. Alio

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引用次数: 0

Abstract

Purpose

To describe a case of well-documented corneal stroma transparency improvement following the intrastromal implantation of autologous adipose-derived mesenchymal stem cells (ADASC) in a keratoconic patient with established stromal scars.

Observations

ADASC were isolated by elective liposuction, and a solution composed of 3x106 ADASC contained in 1mL saline was used to soak a corneal intrastromal pocket created with femtosecond laser at mid-depth. No signs of inflammation or rejection were observed. One year after surgery, we observed a complete restoration of the pre-existing corneal stroma scars, observed both clinically and by anterior segment OCT. The rest of the visual and topographic parameters did not show relevant changes except for the patient's refractive sphere. OCT showed a thin new layer of neocollagen deposited at the surgical plane. Total stroma optical density (OD) improved from 51.5 to 41.2 GSU, anterior stroma OD improved from 55.9 to 42.8 GSU, and posterior stroma OD improved from 46.9 to 39.6 GSU.

Conclusions and importance

This clinical case provides new clinical evidence supporting the use of intrastromal mesenchymal stem cell implantation to solve or alleviate established corneal scars.

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来源期刊

American Journal of Ophthalmology Case Reports Medicine-Ophthalmology

CiteScore

2.40

自引率

0.00%

发文量

513

审稿时长

16 weeks

期刊介绍： The American Journal of Ophthalmology Case Reports is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished case report manuscripts directed to ophthalmologists and visual science specialists. The cases shall be challenging and stimulating but shall also be presented in an educational format to engage the readers as if they are working alongside with the caring clinician scientists to manage the patients. Submissions shall be clear, concise, and well-documented reports. Brief reports and case series submissions on specific themes are also very welcome.