Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets

IF 2 Q3 NEUROSCIENCES
Zhiye Chen , Jian He , Yating Guo , Yue Hao , Wentao Lv , Zexin Chen , Junqiang Wang , Yijian Yang , Kaiyue Wang , Zhikun Liu , Qian Ouyang , Zhangjie Su , Pingsheng Hu , Gelei Xiao
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引用次数: 0

Abstract

In all epithelial cells, the adherent junctions (AJs) with cadherin as the core play an important role in the maintenance of the connection and the formation of apical-basal polarity. The ependymal cells close to the ventricular system rely on AJs with N-cadherin at the core to maintain their normal morphology and function. Therefore, it has an important impact on the function and disease of the central nervous system. Hydrocephalus is a pathological phenomenon of excessive cerebrospinal fluid accumulating in the ventricular system accompanied by continuous ventricular dilatation, which can be divided into obstructive hydrocephalus and communicating hydrocephalus according to the pathogenesis. Obstructive hydrocephalus is often associated with excessive ependymal cells produced by differentiation of radial glial cells. The etiology of communicating hydrocephalus is mainly related to the dyskinesia of cerebrospinal fluid. In addition, the damage of the brain barrier can lead to brain edema and aggravate the symptoms. At present, the researches on the pathogenesis of hydrocephalus are mainly focused on the development of ependymal cells and cilia, while less attention has been paid to molecules such as AJs, which play an important role in maintaining the polarity of ependymal cells. This paper discusses the formation and function of AJs and their role in preventing hydrocephalus by preserving the polarity of ependymal cilia, regulating the number of ependymal cells, and upholding the brain barrier integrity to impede hydrocephalus exacerbation, which provides a new direction for the study of hydrocephalus.
粘附连接:生理学,在脑积水中的作用和潜在的治疗靶点
在所有上皮细胞中,以钙粘蛋白为核心的粘附连接(AJs)在维持连接和形成顶基极性方面起着重要作用。靠近心室系统的室管膜细胞依赖以n -钙粘蛋白为核心的AJs来维持其正常形态和功能。因此,它对中枢神经系统的功能和疾病有重要的影响。脑积水是脑脊液过多积聚在脑室系统并伴有脑室持续扩张的病理现象,根据发病机制可分为阻塞性脑积水和交通性脑积水。梗阻性脑积水常与放射状胶质细胞分化产生的室管膜细胞过多有关。交通性脑积水的病因主要与脑脊液运动障碍有关。此外,脑屏障的损伤可导致脑水肿,加重症状。目前对脑积水发病机制的研究主要集中在室管膜细胞和纤毛的发育上,而对维持室管膜细胞极性起重要作用的AJs等分子关注较少。本文探讨AJs的形成和功能,以及AJs通过维持室管膜纤毛极性、调节室管膜细胞数量、维护脑屏障完整性以阻止脑积水恶化等预防脑积水的作用,为脑积水的研究提供新的方向。
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来源期刊
IBRO Neuroscience Reports
IBRO Neuroscience Reports Neuroscience-Neuroscience (all)
CiteScore
2.80
自引率
0.00%
发文量
99
审稿时长
14 weeks
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