Controlled Electrochemical C4 Sulfonylation of 1(2H)-isoquinolone derivatives: Through the isomerization of N-radical to C-radical

Abstract

Herein, we report the development of an efficient and straightforward electrochemical oxidation methodology for synthesizing 4-sulfonylisoquinolin-1(2H)-ones. The protocol exhibits remarkable versatility, accommodating a broad substrate scope and tolerating a wide range of functional groups, thereby enabling successful large-scale applications. Preliminary mechanistic studies suggest that the electrochemical oxidation generates an N-radical, which subsequently isomerizes to a C-radical.