Recent advancements in catalytic peroxidation of alkenes: Synthetic approach and process optimization

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-01-24 DOI:10.1016/j.tet.2025.134492

Priteeparna Das, Piyusa Priyadarsan Pattanaik, Rana Chatterjee, Rambabu Dandela

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Abstract

Di-functionalization of alkene is a compelling area of synthetic interest due to their natural prevalence and significant antimalarial and antimicrobial activities. Nevertheless, chemoselective and regioselective peroxidation of alkenes employing various peroxy reagents is a distinct challenge and equivalent amounts of wastes are generated leading to formation of unwanted by-products and require harsh reaction conditions. On contrary, tert-butyl hydroperoxide (TBHP) associated with relatively high stability of reagent, risk minimization of overly reactive agents, and wide scope of reactions without extreme reactivity. For the first time we have highlighted the recent reports in the catalytic synthesis of acyclic peroxides using TBHP, particularly studied over the period of last 10 years. Also, we have incorporated the insight of metal catalysts and illustrated the reaction mechanism for catalytic peroxidation of various alkenes. The catalytic performance and optimization of reaction parameters are also elucidated.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.