Towards the first synthetic eukaryotic cell

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Biosafety and Health Pub Date : 2024-12-01 DOI:10.1016/j.bsheal.2024.11.001

Wangyue Xu , Yue Teng , Sijie Zhou

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Abstract

With the rapid advance in synthetic biology and the expanding field of synthetic genomics, the realization of a redesigned yeast genome has become an achievable milestone. Multiple eukaryotic chromosomes, meticulously designed and synthesized, are now being systematically integrated to create an entirely synthetic eukaryotic cell. This comprehensive review examines the fundamental design principles and construction strategies, highlighting critical technological breakthroughs in pursuing the first synthetic eukaryotic cell. Additionally, it underscores the critical contributions of the Sc2.0 project, which has provided essential tools and engineered cellular platforms that have significantly accelerated research and industrial progress. The ethical and legal implications arising from synthetic eukaryotic life are also explored, offering insights into future research directions for synthetic eukaryotic genomes. The remarkable advances in deoxyribonucleic acid synthesis hold immense potential, promising to unlock new opportunities across medicine, industry, agriculture, and research.

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走向第一个合成真核细胞

随着合成生物学的快速发展和合成基因组学领域的不断扩大，重新设计酵母基因组的实现已成为一个可实现的里程碑。多个真核染色体，精心设计和合成，现在正被系统地整合，以创造一个完全合成的真核细胞。这篇全面的综述检查了基本的设计原则和构建策略，强调了在追求第一个合成真核细胞的关键技术突破。此外，它还强调了Sc2.0项目的重要贡献，该项目提供了重要的工具和工程蜂窝平台，大大加快了研究和工业进步。本文还探讨了合成真核生物产生的伦理和法律问题，为合成真核生物基因组的未来研究方向提供了见解。脱氧核糖核酸合成的显著进步具有巨大的潜力，有望在医学、工业、农业和研究领域开辟新的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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