Functional connectivity-based compensation in the brains of non-demented older adults and the influence of lifestyle: A longitudinal 7-year study

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-02-04 DOI:10.1016/j.neuroimage.2025.121075

Pascal Frédéric Deschwanden , Isabel Hotz , Susan Mérillat , Lutz Jäncke

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引用次数: 0

Abstract

Introduction

The aging brain is characterized by structural decline and functional connectivity changes towards dedifferentiation, leading to cognitive decline. To some degree, the brain can compensate for structural deterioration. In this study, we aim to answer two questions: Where can we detect longitudinal functional connectivity-based compensation in the brains of cognitively healthy older adults? Can lifestyle predict the strength of this functional compensation?

Methods

Using longitudinal data from 228 cognitively healthy older adults, we analyzed five measurement points over 7 years. Network-based statistics and latent growth modeling were employed to examine changes in structural and functional connectivity, as well as potential functional compensation for declines in processing speed and memory. Random forest and linear regression were used to predict the amplitude of compensation based on demographic, biological, and lifestyle factors.

Results

Both functional and structural connectivity showed increases and decreases over time, depending on the specific connection and measure. Increased functional connectivity of 27 connections was linked to smaller declines in cognition. Five of those connections showed simultaneous decreases in fractional anisotropy, indicating direct compensation. The degree of compensation depended on the type of compensation and the cognitive ability, with demographic, biological, and lifestyle factors explaining 3.4–8.9% of the variance.

Conclusions

There are widespread changes in structural and functional connectivity in older adults. Despite the trend of dedifferentiation in functional connectivity, we detected both direct and indirect compensatory subnetworks that mitigated the decline in cognitive performance. The degree of compensation was influenced by demographic, biological, and lifestyle factors.

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.