Sensitivity enhanced SPR/LSPR biosensor based on Au/PDA/AuNps co-modified PCF for rabbit IgG detection

IF 2.6 3区计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Optical Fiber Technology Pub Date : 2025-02-03 DOI:10.1016/j.yofte.2025.104148

Zhiyang Wang, Ailing Zhang, Pengxiang Chang, Yanmei Shi, Zhen Li

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Abstract

A photonic crystal fiber (PCF)-based SPR biosensor co-modified by Au film, polydopamine (PDA) and Au nanoparticles (AuNps) is proposed. The refractive index(RI) sensitivity of the sensor is enhanced by the coupling between the SPR inspired in the Au film and the localized surface plasmon resonance (LSPR) inspired in AuNps, as well as the high RI of the PDA. The experimental results show that the PCF-Au-PDA-AuNps sensor obtains a high RI sensitivity of 3523.10 nm/RIU in the RI range of 1.335–––1.365, which is 2.07 times of that of the PCF-Au sensor. In addition, in order to bioassay to rabbit IgG, an extra layer of PDA with excellent adhesion and biocompatibility properties is modified on the surface of AuNps to anchor a layer of goat anti-rabbit Immunoglobulin G(IgG). The bio-sensitivity of the sensor for rabbit IgG reaches 0.951 nm/(µg/mL), and the limit of detection (LOD) is 0.021 µg/mL. Due to its good biosensing performance, this fiber-optic biosensor based on SPR-LSPR coupling is suitable to be applied in clinical disease diagnosis and immunoassay.

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来源期刊

Optical Fiber Technology 工程技术-电信学

CiteScore

4.80

自引率

11.10%

发文量

327

审稿时长

63 days

期刊介绍： Innovations in optical fiber technology are revolutionizing world communications. Newly developed fiber amplifiers allow for direct transmission of high-speed signals over transcontinental distances without the need for electronic regeneration. Optical fibers find new applications in data processing. The impact of fiber materials, devices, and systems on communications in the coming decades will create an abundance of primary literature and the need for up-to-date reviews. Optical Fiber Technology: Materials, Devices, and Systems is a new cutting-edge journal designed to fill a need in this rapidly evolving field for speedy publication of regular length papers. Both theoretical and experimental papers on fiber materials, devices, and system performance evaluation and measurements are eligible, with emphasis on practical applications.