Associations between adverse childhood experiences and subjective cognitive decline: A scoping review

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2025-01-26 DOI:10.1016/j.archger.2025.105773

Areum Kim , Byunghoon “Tony” Ahn , Yeonjin Kim , Jae Won Oh , Jaesub Park , Han Wool Jung , Woo Jung Kim

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引用次数: 0

Abstract

Background

Long-term health effects of adverse childhood experiences (ACEs) include cognitive decline that occurs later in life. Subjective cognitive decline (SCD), recognized as an early indicator of Alzheimer's disease, may present an essential period for intervention in populations with ACEs.

Objective

This review aims to explore the associations between ACEs and SCD, while examining the potential moderating effects of sociodemographic factors

Methods

A systematic search of four databases (Medline, PsycINFO, CINAHL, and Web of Science) was conducted from inception to July 2024. Eligible studies included adults with a history of ACEs and self-reported SCD. In total, twelve studies were included, primarily using U.S.-based samples, with sample sizes ranging from 46 to over 195,000 participants.

Results

The evidence of a dose-response relationship highlights the link between ACEs and SCD. The risk of SCD increases among adults over 65, lower-income groups, and sexual minorities. However, gender differences were inconsistently observed across studies. Mental health conditions, particularly depression is a significant risk factor.

Conclusions

Early screening and intervention for SCD among individuals with high ACE exposure may help delay the progression to severe cognitive impairment. However, the reliance on cross-sectional studies and high risk of bias limit causal inferences. Future research should explore longitudinal studies with diverse populations to clarify causal pathways and the role of sociodemographic factors in the ACE-SCD relationship.

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不良童年经历与主观认知能力下降之间的关系：一项范围综述

童年不良经历（ace）对健康的长期影响包括在以后生活中出现的认知能力下降。主观认知能力下降（SCD）被认为是阿尔茨海默病的早期指标，可能是ace患者进行干预的必要时期。目的探讨ace与SCD之间的关系，并探讨社会人口学因素对SCD的调节作用。方法系统检索Medline、PsycINFO、CINAHL和Web of Science数据库，检索时间自成立至2024年7月。符合条件的研究包括有ace病史和自我报告SCD的成年人。总共包括12项研究，主要使用美国的样本，样本量从46到195,000多名参与者不等。结果ace与SCD之间存在剂量-反应关系。65岁以上的成年人、低收入群体和性少数群体患SCD的风险增加。然而，在研究中观察到的性别差异并不一致。心理健康状况，特别是抑郁症是一个重要的风险因素。结论对ACE高暴露个体进行SCD早期筛查和干预可能有助于延缓SCD向严重认知障碍的发展。然而，对横断面研究的依赖和高偏倚风险限制了因果推断。未来的研究应探索不同人群的纵向研究，以阐明ACE-SCD关系中的因果途径和社会人口因素的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.