Naturally-occurring carnosic acid as a promising therapeutic agent for skin inflammation via targeting STAT1

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2025-02-01 DOI:10.1016/j.phymed.2025.156442

Aike Wu , Yunying Wang , Rui Mao , Zixin Tan , San Xu , Juan Long , Qian Wang , Zhixiang Zhao , Hongfu Xie , Zhili Deng , Ji Li , Mengting Chen

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引用次数: 0

Abstract

Background

Psoriasis and rosacea are prevalent chronic inflammatory skin disorders driven by aberrant interactions between skin-resident keratinocytes and immune cells. Natural products represent a largely untapped source of novel therapeutic agents for various diseases. This study aimed to identify an effective natural product for treating psoriasis and rosacea and to elucidate its underlying mechanism of action.

Methods

Bioinformatics and network pharmacology approaches were employed to identify potential drug candidates for these conditions. Psoriasis-like and rosacea-like inflammation models were established in mice to assess the in vivo therapeutic effects of carnosic acid. In vitro experiments were performed to investigate the molecular mechanisms underlying carnosic acid's anti-inflammatory activity.

Results

Through bioinformatics and network pharmacology, carnosic acid, a plant-derived phenolic diterpene, was identified as a promising candidate for these skin disorders. Functional assays demonstrated that carnosic acid effectively inhibited skin inflammation in both imiquimod-induced psoriasis and LL37-induced rosacea mouse models. Mechanistically, carnosic acid bound directly to STAT1, inhibiting its phosphorylation and subsequent transcriptional activation, which led to a reduction in the production of STAT1-mediated inflammatory factors in keratinocytes. Topical application of carnosic acid significantly alleviated clinical symptoms in both psoriasis and rosacea models.

Conclusion

These findings suggest that carnosic acid holds potential as a therapeutic agent for STAT1-mediated skin inflammation.

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.