Neurodevelopment within the first three years of life does not predict psychotic experiences at age 10: A prospective cohort study

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-02-01 DOI:10.1016/j.schres.2025.01.025

María Hernández-Lorca , Martin Køster Rimvall , Jens Richardt Møllegaard Jepsen , Julie B. Rosenberg , Parisa Mohammadzadeh , Birgitte Fagerlund , Birte Glenthøj , Bo Chawes , Klaus Bønnelykke , Bjørn H. Ebdrup , Rebecca Kofod Vinding

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Abstract

Background

Early childhood developmental delays and lower cognitive and motor function have been found to be related to psychotic experiences (PE) in middle childhood. These findings suggest a neurodevelopmental pathway to PE in childhood. This study examined if prospectively assessed neurodevelopment in infancy from birth to age 3 predicted PE at age 10.

Methods

We included data from the population-based prospective longitudinal cohort COPSAC₂₀₁₀ (n = 700). Parents reported on children milestones starting at 1 week old, language acquisition at 1 and 2 years of age, and children were evaluated on cognition at 2.5 years and general development at 3 years. At age 10, children were clinically assessed regarding PE. We used adjusted logistic regression models to assess the association between developmental within the first years of life and later PE.

Results

We evaluated 593 children at 10 years regarding PE, of which 77 (13 %) reported having experienced PE. We did not find significant associations between early life neurodevelopment and childhood PE. Analyses excluding children with neurodevelopmental diagnosis (i.e, ADHD, autism and tics) yielded similar results.

Conclusions

Delays in developmental milestones, language acquisition, and cognition during the first 3 years of life were not associated with PE in middle childhood. The findings do not support that childhood PE occurs associated with atypical early neurodevelopment. Given that we report results on one time point PE, clarification of associations with persistent PE are warranted.

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.