Consanguinity and hearing loss prevalence among Saudi Arabia population

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology Pub Date : 2025-02-01 DOI:10.1016/j.ijporl.2024.112209

Shawq Fayez Aljabri , Shawg Saleh Alrumaih , Yousef M Al Mashhrawi , Muhannad Sulaiman Alhusayni , Rawan Abdulrahman Bayamin , Reem Mansour Kublan Alkublan , Amal Binhazzaa

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引用次数: 0

Abstract

Background

Childhood hearing loss (CHL) is a condition that can have a variety of causes, including genetic and environmental and its prevalence is thought to be high in Saudi Arabian population mainly due to consanguineous unions. This systematic literature review aims to conclude the prevalence of hereditary hearing loss and its risk factors among the Saudi population.

Methods

In September 2023, a thorough search was performed on the PubMed, CENTRAL, MEDLINE, and EMBASE databases. Two reviewers independently reviewed the literature and gathered data. The search criteria encompassed ethics and dissemination. The systematic review and meta-analysis utilized information sourced from openly accessible research articles, thereby avoiding the involvement of any individuals or animals in the study.

Results

The search identified nine relevant studies. Consanguinity prevalence ranged from 21.1 % to 80.8 %, with first cousin marriages being common. The prevalence of CHL among offspring from consanguineous marriages was consistently higher than non-consanguineous unions. A meta-analysis was not feasible due to heterogeneity in study designs and outcomes. The risk of CHL in offspring from consanguineous marriages was significantly elevated, as evidenced by Almazroua's study (2020) reporting a 3.5 times higher risk. Genetic factors and hereditary influences were underscored by the studies, with variations in prevalence and risk factors.

Conclusion

This systematic review reveals a substantial association between consanguinity and an increased risk of congenital sensorineural hearing loss in the Saudi Arabian population. The prevalence of consanguinity, coupled with the consistently higher prevalence of CHL among offspring from such unions, emphasizes the need for targeted public health interventions. Educational programs, genetic counseling, and expanded premarital screening programs are warranted to address the impact of consanguinity on hearing health in Saudi Arabia.

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来源期刊

International journal of pediatric otorhinolaryngology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.70%

发文量

276

审稿时长

62 days

期刊介绍： The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.