Junceellolide Q, a new polyacetoxybriarane from the delicate sea whip octocoral Junceella fragilis

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-07 DOI:10.1016/j.phytol.2025.01.997

Yih-Gang Goan , Mingzi M. Zhang , Lun Kelvin Tsou , Zhi-Hong Wen , Chia-Ching Liaw , Yu-Chi Lin , Su-Ying Chien , Yu-Jen Wu , Jih-Jung Chen , Hai Nhat Do , Pei-Luen Jiang , Ping-Jyun Sung

引用次数: 0

Abstract

In this study, chemical screening of a zooxanthella-associated octocoral Junceella fragilis led to the identification of four briarane-type diterpenoids: one new compound, junceellolide Q (1), and three known analogs: fragilolide J (2), junceellin (3), and frajunolide N (4). The structures of compounds 2–4 were confirmed through single-crystal X-ray diffraction (SC-XRD) analysis, while the structure of compound 1 was elucidated using 2D-NMR techniques. Briaranes 1 and 2 were active in enhancing alkaline phosphatase (ALP) activity.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.