{"title":"Transanal TME noninferior to the laparoscopic approach","authors":"Peter Sidaway","doi":"10.1038/s41571-025-00997-0","DOIUrl":null,"url":null,"abstract":"<p>Patients with resectable mid–low rectal cancers often undergo total mesorectal excision (TME) surgery. Over the past decade, considerable research interest has been focused on minimally invasive TME procedures that might offer improved perioperative outcomes and preservation of sphincter function, including laparoscopic and transanal approaches. Despite some evidence of an increased risk of local recurrence with the transanal approach, only limited data on long-term outcomes are available. Now, data from the phase III TaLaR trial indicate similar 3-year survival outcomes among patients undergoing these procedures.</p><p>A total of 1,115 patients with stage I–III mid–low rectal cancer (located within 10 cm of the rectal verge) requiring TME surgery were randomly assigned (1:1) to undergo transanal or laparoscopic TME across 16 centres in China. Noninferior 3-year disease-free survival (DFS) was the primary end point.</p>","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"14 1","pages":""},"PeriodicalIF":81.1000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Clinical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41571-025-00997-0","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Patients with resectable mid–low rectal cancers often undergo total mesorectal excision (TME) surgery. Over the past decade, considerable research interest has been focused on minimally invasive TME procedures that might offer improved perioperative outcomes and preservation of sphincter function, including laparoscopic and transanal approaches. Despite some evidence of an increased risk of local recurrence with the transanal approach, only limited data on long-term outcomes are available. Now, data from the phase III TaLaR trial indicate similar 3-year survival outcomes among patients undergoing these procedures.
A total of 1,115 patients with stage I–III mid–low rectal cancer (located within 10 cm of the rectal verge) requiring TME surgery were randomly assigned (1:1) to undergo transanal or laparoscopic TME across 16 centres in China. Noninferior 3-year disease-free survival (DFS) was the primary end point.
期刊介绍：
Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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