Adherence to the Mediterranean diet and colorectal cancer risk: a large case control study in the Moroccan population.

IF 3 3区医学 Q2 NUTRITION & DIETETICS

Public Health Nutrition Pub Date : 2025-02-06 DOI:10.1017/S1368980025000199

Khaoula El Kinany, Zineb Hatime, Achraf El Asri, Abdelilah Benslimane, Meimouna Deoula, Btissame Zarrouq, Pagona Lagiou, Karima El Rhazi

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引用次数: 0

Abstract

Objective: The Mediterranean diet (MD) is a dietary pattern associated with several health benefits, including reduction of risk for various cancers. We conducted a study to investigate associations between adherence to the MD and colorectal cancer (CRC) subtype risk among Moroccan adults.

Design: A matched case-control study.

Setting: The five major university hospitals in Morocco.

Participants: A total of 3032 subjects (1516 CRC patients and 1516 controls) matched on age, sex and center, were recruited between September 2009 and February 2017 at five major hospitals in Morocco. Diet was assessed using a validated Food Frequency Questionnaire (FFQ). Adherence to the Mediterranean diet was assessed through a score, ranging from 0 (no adherence) to 10 (maximal adherence) and divided into three categories (low, middle and high). Conditional logistic regression was performed to calculate multivariable odd ratios (OR) and 95% confidence intervals (CI) with low adherence (score 0-3) as referent, adjusting for potential confounding factors.

Results: Close adherence to the Mediterranean diet (score 6-9) was associated with reduced risk of CRC (ORa = 0.74, 95% CI 0.63-0.86); rectal cancer (ORa = 0.73, 95% CI 0.58- 0.90) and colon cancer (ORa = 0.74, 95% CI 0.60-0.92).

Conclusion: Our study, conducted in a southern Mediterranean population, adds to the evidence suggesting a protective effect of MD against CRC risk.

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来源期刊

Public Health Nutrition 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.10

自引率

6.20%

发文量

521

审稿时长

3 months

期刊介绍： Public Health Nutrition provides an international peer-reviewed forum for the publication and dissemination of research and scholarship aimed at understanding the causes of, and approaches and solutions to nutrition-related public health achievements, situations and problems around the world. The journal publishes original and commissioned articles, commentaries and discussion papers for debate. The journal is of interest to epidemiologists and health promotion specialists interested in the role of nutrition in disease prevention; academics and those involved in fieldwork and the application of research to identify practical solutions to important public health problems.