Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 - 2021).

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI:10.2147/IDR.S499804

Hai Ha Long Le, Luong Cong Thuc, Thang Ba Ta, Tien Viet Tran, Dinh Viet Hung, Hoang Trung Kien, Minh Nhat Le, Vu Huy Luong, Vinh Thi Ha Nguyen, Hoa Quynh Pham, Hung Van Le, Nguyen Hoang Viet, Le Huy Hoang, Tram Thuy Nguyen, Mixay Latsavong, Tuan Dinh Le, Dao Trong Tuan, Nguyen Van An

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Abstract

Purpose: In a Vietnamese teaching hospital, this study examined the prevalence and patterns of antimicrobial resistance (AMR) of common bacteria isolated from hospitalized patients with urinary tract infections (UTIs) between 2014 and 2021.

Methods: From 4060 urine samples collected, common pathogens were isolated using quantitative culture on brilliance UTI Clarity agar and blood agar. Bacterial identification, antimicrobial susceptibility testing, and multidrug resistance (MDR) classification followed standardized techniques. Bacteria with a frequency of less than 2% were excluded. Statistical analysis was performed using R software, with the chi-square test applied and significance set at p < 0.05.

Results: Of 4060 urine samples collected, 892 (22.0%) had positive results for common infections. Gram-negative bacteria predominated (591/892; 66.3%), with Escherichia coli being the most prevalent (336/892; 37.7%). Enterococcus spp. (152/892; 17.0%) was the leading Gram-positive pathogen. Some antibiotics had significant resistance rates, especially in Gram-negative bacteria, with ampicillin having the greatest resistance rate (92.8%). Carbapenems and nitrofurantoin remained generally effective. Among Gram-positive bacteria, high resistance was seen for macrolides ranging from 85.5% (azithromycin) to 89.8% (erythromycin), and for tetracyclines, ranging from 0% (teicoplanin) to 85.2% (tetracycline). There was no resistance to tigecycline and teicoplanin, indicating their potential efficacy against multidrug resistance (MDR) bacteria causing UTIs. MDR rates were higher in Gram-negative bacteria (64.8% versus 43.5%), with Klebsiella pneumoniae having the highest rate (78.7%).

Conclusion: This study underscores the urgent need for ongoing surveillance of AMR patterns in Vietnam and emphasizes the significance of efficient infection prevention methods, prudent use of antibiotics, and targeted interventions to combat antimicrobial resistance.

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2014 - 2021年越南某教学医院尿路感染住院患者主要抗生素耐药模式

目的：在越南一家教学医院，本研究调查了2014年至2021年住院尿路感染（uti）患者中分离的常见细菌的抗微生物药物耐药性（AMR）的流行情况和模式。方法：收集4060份尿样，采用荧光UTI透明琼脂和血琼脂定量培养分离常见病原菌。细菌鉴定、药敏试验和多药耐药（MDR）分类采用标准化技术。排除频率小于2%的细菌。采用R软件进行统计学分析，采用卡方检验，显著性设置为p < 0.05。结果：4060份尿样中，常见感染阳性892份（22.0%）。革兰氏阴性菌占多数（591/892）；66.3%)，其中大肠杆菌最为常见(336/892；37.7%)。肠球菌(152/892；17.0%)为革兰氏阳性致病菌。部分抗生素耐药率显著，尤其是革兰氏阴性菌，以氨苄西林耐药率最高（92.8%）。碳青霉烯类和呋喃妥英仍然普遍有效。革兰氏阳性菌对大环内酯类（阿奇霉素）和四环素的高耐药范围分别为85.5% ~ 89.8%和0% ~ 85.2%（四环素）。对替加环素和替柯planin均无耐药性，提示其对多药耐药（MDR）细菌引起的尿路感染具有潜在疗效。革兰氏阴性菌的耐多药率较高（64.8%对43.5%），肺炎克雷伯菌的耐多药率最高（78.7%）。结论：本研究强调了对越南抗菌素耐药性模式进行持续监测的迫切需要，并强调了有效的感染预防方法、谨慎使用抗生素和有针对性的干预措施对对抗抗菌素耐药性的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.