Influencing factors of health-related quality-of-life perceived by both children/adolescents patients with type-1 diabetes mellitus and their parents: A North-African study.

Q2 Pharmacology, Toxicology and Pharmaceutics
F1000Research Pub Date : 2025-01-17 eCollection Date: 2024-01-01 DOI:10.12688/f1000research.148074.1
Imen Ben Abdesselem, Raoudha Kebeili, Khansa Derbel, Hichem Ben Said, Lamia Boughamoura, Jihene Bouguila, Helmi Ben Saad
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Abstract

Aim: To determine the influencing factors of health-related quality-of-life (HRQoL) perceived by North-African children/adolescents with type-1 diabetes-mellitus (T1DM) and their parents.

Methods: It was a cross sectional study conducted in Tunisia. A total of 116 patients ( ie ; 43 children and 73 adolescents) and their parents were included. The Arabic validated version of the Pediatric Generic Core Quality-of-Life Inventory 4.0-Scale (PedsQL4.0) was used to evaluate the HRQoL of children/adolescents as perceived by patients and parents. The dependent data were the patients' self-report and the parents' proxy-report of the PedsQL4.0 total scores, and the independent data were the patients and parents characteristics.

Results: Patients' PedsQL4.0 total score was influenced significantly by siblings in the family > 2; lipodystrophy, and glycosylated hemoglobin (HbA1C). The combination of these factors explained 34.84% of the PedsQL4.0 total score variability. Parents' PedsQL4.0 total score was influenced significantly by lipodystrophy, siblings; body mass index (BMI), hypoglycemia episodes, and HbA1C. The combination of these factors explained 56.92% of the PedsQL4.0 total score variability.

Conclusion: T1DM patients self-reported HRQoL was influenced by siblings in the family > 2; lipodystrophy, and HbA1C. The parents' proxy-report HRQoL was influenced by lipodystrophy, siblings, BMI, hypoglycemia episodes, and HbA1C.

儿童/青少年1型糖尿病患者及其父母感知健康相关生活质量的影响因素:一项北非研究
目的:了解北非地区1型糖尿病(T1DM)儿童/青少年及其父母健康相关生活质量(HRQoL)的影响因素。方法:在突尼斯进行横断面研究。共116例患者(即;包括43名儿童和73名青少年)及其父母。采用阿拉伯语验证版儿科通用核心生活质量量表4.0 (PedsQL4.0)评估患者和家长感知的儿童/青少年的HRQoL。依赖数据为患者自我报告和家长对PedsQL4.0总分的代理报告,独立数据为患者和家长特征。结果:家庭中兄弟姐妹对患者的PedsQL4.0总分有显著影响[2];和糖化血红蛋白(HbA1C)。这些因素的组合解释了34.84%的PedsQL4.0总分变异。父母PedsQL4.0总分受脂肪营养不良、兄弟姐妹影响显著;体重指数(BMI)、低血糖发作和HbA1C。这些因素的组合解释了56.92%的PedsQL4.0总分变异性。结论:T1DM患者自我报告的HRQoL受家族兄弟姐妹的影响[2];脂肪营养不良和糖化血红蛋白。父母代理报告的HRQoL受脂肪营养不良、兄弟姐妹、BMI、低血糖发作和HbA1C的影响。
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来源期刊
F1000Research
F1000Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
5.00
自引率
0.00%
发文量
1646
审稿时长
1 weeks
期刊介绍: F1000Research publishes articles and other research outputs reporting basic scientific, scholarly, translational and clinical research across the physical and life sciences, engineering, medicine, social sciences and humanities. F1000Research is a scholarly publication platform set up for the scientific, scholarly and medical research community; each article has at least one author who is a qualified researcher, scholar or clinician actively working in their speciality and who has made a key contribution to the article. Articles must be original (not duplications). All research is suitable irrespective of the perceived level of interest or novelty; we welcome confirmatory and negative results, as well as null studies. F1000Research publishes different type of research, including clinical trials, systematic reviews, software tools, method articles, and many others. Reviews and Opinion articles providing a balanced and comprehensive overview of the latest discoveries in a particular field, or presenting a personal perspective on recent developments, are also welcome. See the full list of article types we accept for more information.
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