Cardioprotective Effects of Adiponectin-Stimulated Autophagy.

Q2 Medicine
Journal of Lipid and Atherosclerosis Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI:10.12997/jla.2025.14.1.40
Eddie Tam, Mireille Ouimet, Gary Sweeney
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引用次数: 0

Abstract

Cardiovascular diseases (CVDs), including heart failure, pose a significant economic and health burden worldwide. Current treatment strategies for heart failure are greatly limited, in that they mainly mitigate symptoms or delay further progression. In contrast, therapies aimed at proactively preventing the onset of heart failure could greatly improve outcomes. Adiponectin is an adipocyte-derived hormone that confers an array of cardioprotective effects. It exerts anti-inflammatory effects, improves metabolic function, mitigates endothelial cell dysfunction, and reduce cardiomyocyte cell death. Furthermore, it has gained increasing attention for its ability to activate autophagy, a conserved cellular pathway that facilitates the degradation and recycling of cell components. The disruption of autophagy has been linked to CVDs including heart failure. Additionally, growing evidence also points to specific forms of autophagy, namely mitophagy and lipophagy, as crucial adaptive responses in protection against CVDs. The protective effects of adiponectin, autophagy, mitophagy, and lipophagy against CVDs along with potential therapeutic implications will be discussed.

脂联素刺激的自噬对心脏的保护作用。
心血管疾病(cvd),包括心力衰竭,在世界范围内造成重大的经济和健康负担。目前心力衰竭的治疗策略非常有限,因为它们主要是缓解症状或延缓进一步的进展。相比之下,旨在主动预防心力衰竭发作的治疗可以大大改善结果。脂联素是一种脂肪细胞衍生的激素,具有一系列的心脏保护作用。它具有抗炎作用,改善代谢功能,减轻内皮细胞功能障碍,减少心肌细胞死亡。此外,它因其激活自噬的能力而受到越来越多的关注,自噬是一种促进细胞成分降解和再循环的保守细胞途径。自噬的破坏与包括心力衰竭在内的心血管疾病有关。此外,越来越多的证据还指出,特定形式的自噬,即有丝自噬和脂质自噬,是预防心血管疾病的关键适应性反应。脂联素、自噬、有丝分裂和脂噬对心血管疾病的保护作用以及潜在的治疗意义将被讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Lipid and Atherosclerosis
Journal of Lipid and Atherosclerosis Medicine-Internal Medicine
CiteScore
6.90
自引率
0.00%
发文量
26
审稿时长
12 weeks
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