Evaluation of the Mixing Characteristics of Magnesium Stearate Using Triboelectric Properties.

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI:10.1248/cpb.c24-00694

Kenta Fujinuma, Masataka Ito, Etsuo Yonemochi, Katsuhide Terada, Hironori Suzuki, Shuji Noguchi

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Abstract

Magnesium stearate (MgSt), which is often used as a lubricant in the production of solid formulations, has different stearic acid and palmitic acid contents depending on the lot and manufacturer, resulting in differences in mixability and lubricating effect. However, there are few reports on the effect of the different physical properties of MgSt samples on mixing and tablet formation. Additionally, it is known that the triboelectric properties of components affect the mixability. Overmixing of formulations can decrease tablet hardness. In this study, the triboelectric properties and mixability of MgSt samples with different lots and manufacturers were evaluated. Tablet hardness was used as an index of the mixability of the MgSt samples with various excipients. The triboelectric properties of the MgSt samples depended on the production lot. Mixability was higher when the triboelectric properties of the excipient and MgSt were different. By evaluating the charge properties of MgSt, it should be possible to select the optimum lot and manufacturer of MgSt for specific formulations.

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用摩擦电性能评价硬脂酸镁的混合特性。

硬脂酸镁（MgSt）通常用作固体配方生产中的润滑剂，根据批号和制造商的不同，其硬脂酸和棕榈酸含量不同，从而导致可混合性和润滑效果的差异。然而，关于MgSt样品的不同物理性质对混合和片剂形成的影响的报道很少。此外，已知组件的摩擦电性能影响可混性。配方过度混合会降低片剂的硬度。在本研究中，对不同批号和不同厂家的MgSt样品的摩擦电性能和可混性进行了评价。以片剂硬度作为MgSt样品与各种赋形剂混合性的指标。MgSt样品的摩擦电性能取决于生产批次。当赋形剂和MgSt的摩擦电性能不同时，混合性更高。通过评估MgSt的电荷特性，应该可以为特定配方选择最佳批次和MgSt制造商。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.