Associations between Parity, History of Breastfeeding, and T-cell Profile of Ovarian Tumors.

IF 3.7 3区 医学 Q2 ONCOLOGY
Jennifer M Mongiovi, Mary K Townsend, Allison F Vitonis, Holly R Harris, Jennifer A Doherty, Ana Babic, Jonathan L Hecht, T Rinda Soong, Linda Titus, Jose R Conejo-Garcia, Brooke L Fridley, Shelley S Tworoger, Kathryn L Terry, Naoko Sasamoto
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引用次数: 0

Abstract

Background: Parity and breastfeeding are associated with systemic changes in maternal inflammation and reduced risk of ovarian cancer, but little is known about their impact on the ovarian tumor immune microenvironment.

Methods: We evaluated the associations of self-reported parity and history of breastfeeding with tumor-infiltrating T cells among 1,706 ovarian carcinoma cases with tumor tissue collected across four studies. The abundance of tumor-infiltrating T cells was measured by multiplex immunofluorescence in tumor tissue microarrays. ORs and 95% confidence intervals (CI) for the positivity of tumor immune cells were calculated using beta-binomial models and stratified by histotype.

Results: Compared with ovarian tumors in nulliparous women, there was no association between parity and ovarian tumor T-cell abundance among all histotypes combined but suggestion of increased cytotoxic T cells and T-cell exhaustion among parous women with clear-cell tumors. When restricted to parous women, history of breastfeeding was associated with increased odds for all T-cell types [i.e., total T, cytotoxic T, helper T (Th), regulatory T, and exhausted T cells], with ORs ranging from 1.11 to 1.42. For every 6 months of breastfeeding, we observed increased odds of activated Th-cell infiltration (CD3+CD4+CD69+; OR, 1.13, 95% CI, 0.99-1.29), with a similar association for high-grade serous tumors, but lower odds in clear-cell tumors (OR, 0.43, 95% CI, 0.21-0.87).

Conclusions: History of breastfeeding may alter the ovarian tumor immune microenvironment by modulating the abundance of tumor-infiltrating T cells.

Impact: Although replication is required, history of breastfeeding may play a role in the activation of the ovarian tumor immune response.

胎次、母乳喂养史和卵巢肿瘤T细胞谱之间的关系。
背景:胎次和母乳喂养与母体炎症的全身性改变和卵巢癌风险降低有关,但对其对卵巢肿瘤免疫微环境的影响知之甚少。方法:我们评估了四项研究中收集的1,706例卵巢癌患者肿瘤组织中自我报告胎次和母乳喂养史与肿瘤浸润T细胞的关系。采用肿瘤组织微阵列多重免疫荧光检测肿瘤浸润T细胞的丰度。采用β -二项模型计算肿瘤免疫细胞阳性的优势比(OR)和95%置信区间(CIs),并按组织型分层。结果:与未生育妇女的卵巢肿瘤相比,所有组织类型合并后,胎次与卵巢肿瘤T细胞丰度之间没有相关性,但在有透明细胞肿瘤的已生育妇女中,细胞毒性T细胞和T细胞衰竭增加。当局限于分娩妇女时,母乳喂养史与所有T细胞类型(即总T细胞、细胞毒性T细胞、辅助T细胞、调节性T细胞和耗竭T细胞)的几率增加有关,or范围为1.11-1.42。对于每6个月的母乳喂养,我们观察到活化辅助性T细胞浸润的几率增加(CD3+CD4+CD69+, OR:1.13, 95% CI: 0.99-1.29),与高级别浆液性肿瘤有相似的关联,但透明细胞肿瘤的几率较低(OR:0.43, 95% CI:0.21-0.87)。结论:母乳喂养史可能通过调节肿瘤浸润T细胞的丰度来改变卵巢肿瘤免疫微环境。影响:虽然需要重复,但母乳喂养史可能在激活卵巢肿瘤免疫反应中发挥作用。
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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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