Two-year survival in patients with oncological disease with low muscle reserve, risk of sarcopenia and probable sarcopenia: A post hoc analysis.

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-02-03 DOI:10.1016/j.clnesp.2025.01.051

Carolina Pinzón Ospina, Daniela Ballen Castañeda, María Paula Cubillos-Carreño, Daniela Alejandra Acero Alfonso, Yeny Marjorie Cuellar Fernandez, Jorge Medina-Parra, Montserrat Montes-Ibarra, Ricardo Alfonso Merchán-Chaverra

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引用次数: 0

Abstract

Introduction: Sarcopenia is a clinical syndrome characterized by the loss of muscle mass quantity and quality. Our objective was to establish the prevalence of low muscle reserve, risk of sarcopenia (RIS) and probable sarcopenia (PS) and their associations with survival at two years in hospitalized patients with cancer.

Methods: This was a post hoc analysis of the Nutri-Score and Malnutrition Screening Tool (MST) operational characteristics. Adjusted calf circumference (CC) was used as an indicator of muscle reserve. The RIS was determined using cut-off points of the CC. PS was defined as low hand grip strength (HGS) according to Working Groups on Sarcopenia also the presence of RIS with PS was analysed. A 2-year survival model was constructed.

Results: A total of 137 patients were included: 54% were women, with a mean age of 54.7 ± 15.4 years; 61% had some degree of malnutrition; 48% had low muscle reserve; 42% had RIS; 28% and 38% had PS and 25% had RIS with PS. Severe muscle reserve deficit (Hazard Ratio (HR) = 2.71, 95% Interval Confidence (95% CI) 1.37-5.37), RIS (HR = 2.94 95% 1.66-5.21), PS (HR = 1.85 95% 1.06-3.22) and (HR = 1.94 95% 1.09-3.41) by tow different consensus and RIS with PS (HR = 2.36 95% CI CI 1.33-4.19) were associated with survival.

Conclusion: Severe muscle reserve deficit, RIS and PS are associated with decreased survival in hospitalized patients with oncological disease.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.