Prevalent Types of Peristomal Skin Damage During Chemoradiotherapy and Their Risk Factors.

IF 5.8 3区 医学 Q1 DERMATOLOGY
Yi Chen, Yan Lu, LiJuan Zhang, LaiJuan Li
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Abstract

Significance: Colorectal cancer is currently ranked third in terms of the global cancer incidence. Enterostomy, a common surgical procedure for colorectal cancer treatment, creates a temporary or permanent stoma in the abdominal wall for waste excretion. Cancer itself and the associated treatments, such as chemotherapy and radiation therapy, increase the likelihood of various types of peristomal skin damage. Recent Advances: Recent research has focused on developing more targeted treatment approaches for peristomal moisture-associated skin damage (P-MASD). In addition, studies are investigating the potential of novel wound care products and therapies to enhance healing and reduce the risk of complications. There is also growing interest in understanding the different types except P-MASD during chemoradiotherapy. Different types match the varied treatments. Thus, we aimed to comprehensively review the most prevalent types of peristomal skin damage during chemoradiotherapy and their associated risk factors. Critical Issues: The five prevalent types of peristomal skin damage that occur during chemoradiotherapy are peristomal radiodermatitis, P-MASD, peristomal acneiform rash, peristomal pyoderma gangrenosum, and peristomal abscess/infection/fistula. The risk factors vary depending on the type; however, they include the radiation dose, ileostomy surgery, chemoradiotherapy-associated diarrhea, use of epidermal growth factor receptor inhibitors, inflammatory bowel disease, and unclear factors. Future Directions: This review guides the clinical identification of peristomal skin damage during chemoradiotherapy, laying a solid foundation for developing effective strategies to prevent this condition.

放化疗中常见的肠周皮肤损伤类型及其危险因素。
意义:结直肠癌目前在全球癌症发病率中排名第三。肠造口术是治疗结肠直肠癌的一种常见手术方法,在腹壁上造一个临时或永久性的口,用于排泄废物。癌症本身和相关的治疗,如化疗和放射治疗,增加了各种类型的肠周皮肤损伤的可能性。最近的研究进展:最近的研究集中在开发更有针对性的治疗方法来治疗肠周水分相关皮肤损伤(P-MASD)。此外,研究正在调查新的伤口护理产品和疗法的潜力,以促进愈合和减少并发症的风险。人们对了解放化疗期间除P-MASD外的其他类型也越来越感兴趣。不同的类型对应不同的处理方法。因此,我们的目的是全面回顾放化疗期间最常见的肠周皮肤损伤类型及其相关的危险因素。关键问题:放化疗期间发生的五种常见的瘤周皮肤损伤是:瘤周放射性皮炎、P-MASD、瘤周痤疮样皮疹、瘤周坏疽性脓皮病和瘤周脓肿/感染/瘘。风险因素因类型而异;然而,它们包括辐射剂量、回肠造口手术、放化疗相关腹泻、表皮生长因子受体抑制剂的使用、炎症性肠病和不明确的因素。未来发展方向:本文综述对放化疗过程中组织周皮肤损伤的临床识别提供指导,为制定有效的预防策略奠定坚实的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in wound care
Advances in wound care Medicine-Emergency Medicine
CiteScore
12.10
自引率
4.10%
发文量
62
期刊介绍: Advances in Wound Care rapidly shares research from bench to bedside, with wound care applications for burns, major trauma, blast injuries, surgery, and diabetic ulcers. The Journal provides a critical, peer-reviewed forum for the field of tissue injury and repair, with an emphasis on acute and chronic wounds. Advances in Wound Care explores novel research approaches and practices to deliver the latest scientific discoveries and developments. Advances in Wound Care coverage includes: Skin bioengineering, Skin and tissue regeneration, Acute, chronic, and complex wounds, Dressings, Anti-scar strategies, Inflammation, Burns and healing, Biofilm, Oxygen and angiogenesis, Critical limb ischemia, Military wound care, New devices and technologies.
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