The world's first anabolic-androgenic steroid testing trial: A two-phase pilot combining chemical analysis, results dissemination and community feedback.

IF 5.2 1区 医学 Q1 PSYCHIATRY
Addiction Pub Date : 2025-02-06 DOI:10.1111/add.70009
Timothy Piatkowski, Ross Coomber, Cameron Francis, Emma Kill, Geoff Davey, Sarah Cresswell, Alan White, Madeline Harding, Karen Blakey, Steph Reeve, Brooke Walters, Cheneal Puljevic, Jason Ferris, Monica Barratt
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引用次数: 0

Abstract

Background and aims: The clandestine production and distribution of anabolic-androgenic steroids (AAS) poses health risks due to the uncertainty of their contents. This study aimed to test the chemical content of AAS samples and provide aggregate results back to the community, exploring how these results influenced usage decisions and risk management.

Design: A mixed-methods approach was used, combining chemical analysis of AAS samples with qualitative interviews. Participants submitted samples for testing, and the results were later shared with them. Semi-structured interviews explored participants' perceptions of AAS risks and the impact of testing results on their behaviour.

Setting: The study was conducted at CheQpoint drug checking service in Brisbane, Australia.

Participants: Thirty-two samples were submitted for testing between 19 April and 7 June 2024, with 23 samples analysed. A total of 25 active AAS users participated in interviews.

Measurements: Chemical analyses identified substances present and assessed active ingredient concentrations. Qualitative interviews gathered participants' perceptions, and these data were analysed through iterative categorisation, guided by the Health Belief Model.

Findings: Chemical analysis identified that 13% of samples contained substances different from what was expected. Concentrations of active ingredients were close to expected levels [e.g. testosterone propionate at 96.2 mg/mL (range = 91.39-101.01 mg/mL)]. Interviews identified four key theme categories. Participants sought testing primarily for substance verification, expressing concerns about contamination and dosage. Barriers to testing included limited access and fear of disclosure. While testing was seen as a valuable harm reduction tool, gaps in health guidance and follow-up support were identified as areas for improvement.

Conclusions: Thirteen percent of 23 anabolic-androgenic steroid (AAS) samples analysed contained substances different from what was expected. Interviews with active AAS users highlighted the need for reliable information, accessible testing services and tailored health approaches for AAS use.

世界上第一个合成代谢雄激素类固醇测试试验:化学分析、结果传播和社区反馈相结合的两阶段试验。
背景和目的:合成代谢雄激素类固醇(AAS)的秘密生产和销售由于其含量的不确定性造成健康风险。本研究旨在测试原子吸收剂样品的化学成分,并向社区提供汇总结果,探讨这些结果如何影响使用决策和风险管理。设计:采用混合方法,将原子吸收光谱样品的化学分析与定性访谈相结合。参与者提交样本进行测试,测试结果随后与他们分享。半结构化访谈探讨了参与者对AAS风险的看法以及测试结果对他们行为的影响。环境:本研究在澳大利亚布里斯班的CheQpoint药物检查服务中心进行。参与者:在2024年4月19日至6月7日期间提交了32份样本进行测试,其中23份样本进行了分析。共有25名活跃的AAS用户参与了访谈。测量:化学分析确定物质存在和评估有效成分浓度。定性访谈收集了参与者的看法,并通过健康信念模型指导下的迭代分类对这些数据进行了分析。发现:化学分析发现,13%的样品含有与预期不同的物质。有效成分的浓度接近预期水平[例如,丙酸睾酮为96.2 mg/mL(范围= 91.39-101.01 mg/mL)]。采访确定了四个关键主题类别。参与者寻求检测主要是为了物质验证,表达了对污染和剂量的担忧。测试的障碍包括获取途径有限和害怕披露。虽然检测被视为一种宝贵的减少危害的工具,但在卫生指导和后续支助方面的差距被确定为需要改进的领域。结论:分析的23个合成代谢雄激素(AAS)样品中有13%含有与预期不同的物质。对辅助服务系统活跃用户的访谈强调,需要可靠的信息、可获得的检测服务和为使用辅助服务系统量身定制的保健方法。
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来源期刊
Addiction
Addiction 医学-精神病学
CiteScore
10.80
自引率
6.70%
发文量
319
审稿时长
3 months
期刊介绍: Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines. Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries. Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.
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