{"title":"Advancements in synthetic methodologies and biological applications of lawsone derivatives.","authors":"Ananya Dash, Jasmine Panda, Barsha Samanta, Seetaram Mohapatra","doi":"10.1039/d5ob00020c","DOIUrl":null,"url":null,"abstract":"<p><p>2-Hydroxy-1,4-naphthoquinone, widely recognized as lawsone, is a natural dye obtained from the henna plant (<i>Lawsonia inermis</i>), known for its biological activity and diverse applications in biochemistry and analytical chemistry. As a versatile precursor, it plays a crucial role in synthesizing a wide range of structurally diverse and bioactive molecular scaffolds. This review highlights recent progress in the development of lawsone derivatives, emphasizing their extensive biological activities, such as anticancer, antimicrobial, antioxidant, antimalarial, and metabolic enzyme-targeting activities, as well as their structure-activity relationships. Remarkably, this is the first detailed exploration covering both the biological activities and chemical synthesis of significant lawsone derivatives from 2016 to the present.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5ob00020c","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
2-Hydroxy-1,4-naphthoquinone, widely recognized as lawsone, is a natural dye obtained from the henna plant (Lawsonia inermis), known for its biological activity and diverse applications in biochemistry and analytical chemistry. As a versatile precursor, it plays a crucial role in synthesizing a wide range of structurally diverse and bioactive molecular scaffolds. This review highlights recent progress in the development of lawsone derivatives, emphasizing their extensive biological activities, such as anticancer, antimicrobial, antioxidant, antimalarial, and metabolic enzyme-targeting activities, as well as their structure-activity relationships. Remarkably, this is the first detailed exploration covering both the biological activities and chemical synthesis of significant lawsone derivatives from 2016 to the present.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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