Systems engineering shall adapt itself with the changes of the world. System engineering communities like (AFIS 2022) and (INCOSE 2021) have been developing their visions with the identification of needs that systems engineering shall integrate to address new challenges. The systems engineering discipline shall be now considered at the enterprise level and be included in the governance of the project. Systems engineering and system thinking shall be deployed on all layers of the organization and horizontally to ensure the consistency the definition, production, and all phases of the lifecycle of the system within all involved organizations. The future is paved with unknowns. Systems engineering can integrate new methodologies, new posture to complete its analytical based tools to better face new kinds of complexity. These new challenges are often due to the reallocation of functions and responsibilities between human and machine in the context of autonomous systems. These collaborative socio-technical systems induce new questions for systems engineering which needs to integrate new domain of skills and interacts with new disciplines from the soft sciences.